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Discovery and molecular basis of subtype-selective cyclophilin inhibitors.
Peterson AA, Rangwala AM, Thakur MK, Ward PS, Hung C, Outhwaite IR, Chan AI, Usanov DL, Mootha VK, Seeliger MA, Liu DR. Peterson AA, et al. Among authors: outhwaite ir. Nat Chem Biol. 2022 Nov;18(11):1184-1195. doi: 10.1038/s41589-022-01116-1. Epub 2022 Sep 26. Nat Chem Biol. 2022. PMID: 36163383 Free PMC article.
We further exploited S2 pocket interactions to develop the first cyclophilin E (CypE)-selective inhibitor, which forms a reversible covalent bond with a CypE S2 pocket lysine, and exhibits 30- to >4,000-fold selectivity over other cyclophilins. ...
We further exploited S2 pocket interactions to develop the first cyclophilin E (CypE)-selective inhibitor, which forms a reversible c …
Patterns of invertebrate functional diversity highlight the vulnerability of ecosystem services over a 45-year period.
Greenop A, Woodcock BA, Outhwaite CL, Carvell C, Pywell RF, Mancini F, Edwards FK, Johnson AC, Isaac NJB. Greenop A, et al. Among authors: outhwaite cl. Curr Biol. 2021 Oct 25;31(20):4627-4634.e3. doi: 10.1016/j.cub.2021.07.080. Epub 2021 Aug 18. Curr Biol. 2021. PMID: 34411527 Free article.
Declines in invertebrate biodiversity(1)(,)(2) pose a significant threat to key ecosystem services.(3-5) Current analyses of biodiversity often focus on taxonomic diversity (e.g., species richness),(6)(,)(7) which does not account for the functional role of a species. ...
Declines in invertebrate biodiversity(1)(,)(2) pose a significant threat to key ecosystem services.(3-5) Current analyses of biodiversity of …
Annual estimates of occupancy for bryophytes, lichens and invertebrates in the UK, 1970-2015.
Outhwaite CL, Powney GD, August TA, Chandler RE, Rorke S, Pescott OL, Harvey M, Roy HE, Fox R, Roy DB, Alexander K, Ball S, Bantock T, Barber T, Beckmann BC, Cook T, Flanagan J, Fowles A, Hammond P, Harvey P, Hepper D, Hubble D, Kramer J, Lee P, MacAdam C, Morris R, Norris A, Palmer S, Plant CW, Simkin J, Stubbs A, Sutton P, Telfer M, Wallace I, Isaac NJB. Outhwaite CL, et al. Sci Data. 2019 Nov 5;6(1):259. doi: 10.1038/s41597-019-0269-1. Sci Data. 2019. PMID: 31690719 Free PMC article.
In the UK, annual measures of species status from fine scale data (e.g. 1 1 km) had previously been limited to a few taxa for which structured monitoring data are available, mainly birds, butterflies, bats and a subset of moth species. ...
In the UK, annual measures of species status from fine scale data (e.g. 1 1 km) had previously been limited to a few taxa for which s …
The effects of crop diversity and crop type on biological diversity in agricultural landscapes: a systematic review protocol.
Moss C, Lukac M, Harris F, Outhwaite CL, Scheelbeek PFD, Green R, Berstein FM, Dangour AD. Moss C, et al. Among authors: outhwaite cl. Wellcome Open Res. 2020 Jul 27;4:101. doi: 10.12688/wellcomeopenres.15343.2. eCollection 2019. Wellcome Open Res. 2020. PMID: 32509965 Free PMC article.
We will therefore conduct a systematic review by searching multiple agriculture, ecology and environmental science databases (e.g. Web of Science, Geobase, Agris, AGRICOLA, GreenFILE) to identify studies reporting the impacts of crop diversity and crop type on the biologic …
We will therefore conduct a systematic review by searching multiple agriculture, ecology and environmental science databases (e.g. We …