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Page 1
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.
Hagedorn PH, Brown JM, Easton A, Pierdomenico M, Jones K, Olson RE, Mercer SE, Li D, Loy J, Høg AM, Jensen ML, Gill M, Cacace AM. Hagedorn PH, et al. Among authors: loy j. Nucleic Acid Ther. 2022 Jun;32(3):151-162. doi: 10.1089/nat.2021.0071. Epub 2022 Feb 14. Nucleic Acid Ther. 2022. PMID: 35166597 Free PMC article.
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
Easton A, Jensen ML, Wang C, Hagedorn PH, Li Y, Weed M, Meredith JE, Guss V, Jones K, Gill M, Krause C, Brown JM, Hunihan L, Natale J, Fernandes A, Lu Y, Polino J, Bookbinder M, Cadelina G, Benitex Y, Sane R, Morrison J, Drexler D, Mercer SE, Bon C, Pandya NJ, Jagasia R, Ou Yang TH, Distler T, Grüninger F, Meldgaard M, Terrigno M, Macor JE, Albright CF, Loy J, Hoeg AM, Olson RE, Cacace AM. Easton A, et al. Among authors: loy j. Mol Ther Nucleic Acids. 2022 Aug 4;29:625-642. doi: 10.1016/j.omtn.2022.07.027. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090761 Free PMC article.
2,2'',3,3'',4,4'',5,5''-Octaphenyl-1,1':4',1''-terphenyl and 2',3',5',6'-tetrafluoro-2,2'',3,3'',4,4'',5,5''-octaphenyl-1,1':4',1''-terphenyl.
Budy SM, Nichol GS, Loy DA. Budy SM, et al. Among authors: loy da. Acta Crystallogr C. 2012 Jan;68(Pt 1):o23-7. doi: 10.1107/S0108270111051900. Epub 2011 Dec 9. Acta Crystallogr C. 2012. PMID: 22223283
The title compounds, C(66)H(46), (I), and C(66)H(42)F(4), (II), are polyphenylated arylenes synthesized by one-step Diels-Alder cycloaddition reactions. ...C-H...F interactions have refined H...F distances of 2.572 (15) and 2.642 (16) A, with approximate C-H. …
The title compounds, C(66)H(46), (I), and C(66)H(42)F(4), (II), are polyphenylated arylenes synthesized by one-step Diels-Alder cyclo …
Rediscovering histology: what is new in endoscopy for inflammatory bowel disease?
Solitano V, D'Amico F, Allocca M, Fiorino G, Zilli A, Loy L, Gilardi D, Radice S, Correale C, Danese S, Peyrin-Biroulet L, Furfaro F. Solitano V, et al. Among authors: loy l. Therap Adv Gastroenterol. 2021 Apr 16;14:17562848211005692. doi: 10.1177/17562848211005692. eCollection 2021. Therap Adv Gastroenterol. 2021. PMID: 33948114 Free PMC article. Review.
Improving quality of care in endoscopy of inflammatory bowel disease: can we do better?
Zilli A, Capogreco A, Furfaro F, Allocca M, Roda G, Loy L, Fiorino G, Danese S. Zilli A, et al. Among authors: loy l. Expert Rev Gastroenterol Hepatol. 2020 Sep;14(9):819-828. doi: 10.1080/17474124.2020.1780913. Epub 2020 Jun 22. Expert Rev Gastroenterol Hepatol. 2020. PMID: 32543983 Review.
EXPERT COMMENTARY: Developing an understanding of the patient-reported perception is important for both clinicians and patients, as it facilitates patient engagement with their care. Moreover, implementing education in reporting is crucial f and the use of verifiable datab …
EXPERT COMMENTARY: Developing an understanding of the patient-reported perception is important for both clinicians and patients, as it facil …
D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy.
Luyten K, Van Loy T, Cawthorne C, Deroose CM, Schols D, Bormans G, Cleeren F. Luyten K, et al. Among authors: van loy t. Pharmaceutics. 2021 Oct 5;13(10):1619. doi: 10.3390/pharmaceutics13101619. Pharmaceutics. 2021. PMID: 34683912 Free PMC article.
However, in a hCXCR4-expressing tumor model, tumor uptake of [(18)F]AlF-NOTA-DV1-k-(DV3) was significantly lower (SUV(mean) 0.6 0.2) compared to [(68)Ga]PentixaFor (SUV(mean) 2.9). This might be explained by the high affinity of [(18)F]AlF-NOTA-DV1-k-(DV3) toward bo …
However, in a hCXCR4-expressing tumor model, tumor uptake of [(18)F]AlF-NOTA-DV1-k-(DV3) was significantly lower (SUV(mean) 0.6 0.2) …
Second generation Al(18)F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging.
Spahn MA, Luyten K, Van Loy T, Sathekge M, Deroose CM, Koole M, Schols D, Vanduffel W, De Vos K, Annaert P, Bormans G, Cleeren F. Spahn MA, et al. Among authors: van loy t. Nucl Med Biol. 2024 May-Jun;132-133:108906. doi: 10.1016/j.nucmedbio.2024.108906. Epub 2024 Mar 19. Nucl Med Biol. 2024. PMID: 38518400
Based on these results, we selected the best vector molecule for development of an Al(18)F-labeled ligand, [(18)F]AlF-NOTA-2xDV1(c11sc12s), which was further evaluated in a cell-based binding assay to assess its binding properties and specificity for CXCR4. ...Surpr …
Based on these results, we selected the best vector molecule for development of an Al(18)F-labeled ligand, [(18)F]AlF-NOTA-2xD …
53 results