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Page 1
The cholangiocyte primary cilium in health and disease.
Mansini AP, Peixoto E, Thelen KM, Gaspari C, Jin S, Gradilone SA. Mansini AP, et al. Among authors: thelen km. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1245-1253. doi: 10.1016/j.bbadis.2017.06.006. Epub 2017 Jun 15. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 28625917 Free PMC article. Review.
MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.
Mansini AP, Lorenzo Pisarello MJ, Thelen KM, Cruz-Reyes M, Peixoto E, Jin S, Howard BN, Trussoni CE, Gajdos GB, LaRusso NF, Perugorria MJ, Banales JM, Gradilone SA. Mansini AP, et al. Among authors: thelen km. Hepatology. 2018 Aug;68(2):561-573. doi: 10.1002/hep.29832. Epub 2018 May 21. Hepatology. 2018. PMID: 29406621 Free PMC article.
SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.
Merino-Azpitarte M, Lozano E, Perugorria MJ, Esparza-Baquer A, Erice O, Santos-Laso Á, O'Rourke CJ, Andersen JB, Jiménez-Agüero R, Lacasta A, D'Amato M, Briz Ó, Jalan-Sakrikar N, Huebert RC, Thelen KM, Gradilone SA, Aransay AM, Lavín JL, Fernández-Barrena MG, Matheu A, Marzioni M, Gores GJ, Bujanda L, Marin JJG, Banales JM. Merino-Azpitarte M, et al. Among authors: thelen km. J Hepatol. 2017 Jul;67(1):72-83. doi: 10.1016/j.jhep.2017.02.017. Epub 2017 Feb 22. J Hepatol. 2017. PMID: 28237397 Free PMC article.
HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models.
Peixoto E, Jin S, Thelen K, Biswas A, Richard S, Morleo M, Mansini A, Holtorf S, Carbone F, Pastore N, Ballabio A, Franco B, Gradilone SA. Peixoto E, et al. Among authors: thelen k. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 1;318(6):G1022-G1033. doi: 10.1152/ajpgi.00033.2020. Epub 2020 Apr 27. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32338033 Free PMC article.