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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 2
1973 3
1974 3
1975 8
1976 5
1977 10
1978 10
1979 11
1980 16
1981 40
1982 42
1983 66
1984 69
1985 77
1986 103
1987 122
1988 114
1989 115
1990 135
1991 121
1992 140
1993 160
1994 165
1995 210
1996 208
1997 263
1998 271
1999 264
2000 303
2001 311
2002 307
2003 320
2004 341
2005 401
2006 422
2007 461
2008 483
2009 490
2010 518
2011 569
2012 608
2013 661
2014 713
2015 691
2016 449
2017 384
2018 483
2019 498
2020 534
2021 549
2022 492
2023 421
2024 113

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12,910 results

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Page 1
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, Vitaly K, Itahashi K, Maeda Y, Matsui S, Shibahara T, Yamashita Y, Irie T, Tsuge A, Fukuoka S, Kawazoe A, Udagawa H, Kirita K, Aokage K, Ishii G, Kuwata T, Nakama K, Kawazu M, Ueno T, Yamazaki N, Goto K, Tsuboi M, Mano H, Doi T, Shitara K, Nishikawa H. Kumagai S, et al. Among authors: yamashita y. Nat Immunol. 2020 Nov;21(11):1346-1358. doi: 10.1038/s41590-020-0769-3. Epub 2020 Aug 31. Nat Immunol. 2020. PMID: 32868929
PD-1 expression by CD8(+) T cells and T(reg) cells negatively impacts effector and immunosuppressive functions, respectively. PD-1 blockade induces both recovery of dysfunctional PD-1(+)CD8(+) T cells and enhanced PD-1(+) T(reg) cell-mediated immunosup …
PD-1 expression by CD8(+) T cells and T(reg) cells negatively impacts effector and immunosuppressive functions, respectively. …
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: yamashita y. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
More than 3,000 covalently liganded cysteines were found on functionally and structurally diverse proteins, including many that play fundamental roles in immunology. We further show that electrophilic compounds can impair T cell activation by distinct mechanisms involving …
More than 3,000 covalently liganded cysteines were found on functionally and structurally diverse proteins, including many that play fundame …
The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer.
Nose Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Yamamoto K, Makino T, Takahashi T, Kawashima A, Haruna M, Hirata M, Ueyama A, Iwahori K, Satoh T, Kurokawa Y, Eguchi H, Doki Y, Wada H. Nose Y, et al. Among authors: yamashita k. Cancer Immunol Immunother. 2023 Jan;72(1):169-181. doi: 10.1007/s00262-022-03240-2. Epub 2022 Jul 1. Cancer Immunol Immunother. 2023. PMID: 35776160 Free PMC article.
This CD103(+)PD-1(+)CD8(+) T cell population mainly consisted of central memory T cells, showing the high expression of Ki-67 and few cytotoxic granules. In contrast, effector memory T cells were more frequently observed among CD103(+)PD-1(+)CD8(+) T c …
This CD103(+)PD-1(+)CD8(+) T cell population mainly consisted of central memory T cells, showing the high expression of Ki-67 …
Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H. Komuro H, et al. Among authors: yamashita y. J Immunother Cancer. 2023 Aug;11(8):e007180. doi: 10.1136/jitc-2023-007180. J Immunother Cancer. 2023. PMID: 37544663 Free PMC article.
An exhausted T-cell (exhausted T (Tex)) cluster characterized by the expression of ENTPD1 (CD39), TOX, PDCD1 (PD1), HAVCR2 (TIM3) and other genes, and by T-cell oligoclonality, was identified. ...Stimulating these T cells with predicted cognate peptide …
An exhausted T-cell (exhausted T (Tex)) cluster characterized by the expression of ENTPD1 (CD39), TOX, PDCD1 (PD1), HAVCR2 (TI …
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.
Nagasaki J, Inozume T, Sax N, Ariyasu R, Ishikawa M, Yamashita K, Kawazu M, Ueno T, Irie T, Tanji E, Morinaga T, Honobe A, Ohnuma T, Yoshino M, Iwata T, Kawase K, Sasaki K, Hanazawa T, Kochin V, Kawamura T, Matsue H, Hino M, Mano H, Suzuki Y, Nishikawa H, Togashi Y. Nagasaki J, et al. Among authors: yamashita k. Cell Rep. 2022 Feb 1;38(5):110331. doi: 10.1016/j.celrep.2022.110331. Cell Rep. 2022. PMID: 35108529 Free article.
Here, using single-cell sequencing, we show that TILs include skewed T cell clonotypes, which are characterized by exhaustion (T(ex)) or nonexhaustion signatures (T(non-ex)). Among skewed clonotypes, those in the T(ex), but not those in the T(no …
Here, using single-cell sequencing, we show that TILs include skewed T cell clonotypes, which are characterized by exhaustion (T …
The future of immunotherapy for sarcoma.
Tsukahara T, Emori M, Murata K, Mizushima E, Shibayama Y, Kubo T, Kanaseki T, Hirohashi Y, Yamashita T, Sato N, Torigoe T. Tsukahara T, et al. Among authors: yamashita t. Expert Opin Biol Ther. 2016 Aug;16(8):1049-57. doi: 10.1080/14712598.2016.1188075. Epub 2016 May 27. Expert Opin Biol Ther. 2016. PMID: 27158940 Review.
We also identified a novel memory T cell population, young memory T cells defined by CD73+CXCR3+. Regulation of such memory T stem cells will be useful for peptide vaccination and adoptive cell transfer....
We also identified a novel memory T cell population, young memory T cells defined by CD73+CXCR3+. Regulation of such memory …
Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases.
Abbaoui A, Fatoba O, Yamashita T. Abbaoui A, et al. Among authors: yamashita t. Front Cell Neurosci. 2023 Aug 7;17:1181071. doi: 10.3389/fncel.2023.1181071. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37608988 Free PMC article. Review.
Meningeal immunity is a complex immune environment housing different types of immune cells. Here, we focus on meningeal T cells, possibly the most explored aspect of neuro-immune cell interactions. ...Overall, this review assesses the recent knowledge of meningeal T …
Meningeal immunity is a complex immune environment housing different types of immune cells. Here, we focus on meningeal T cells, poss …
Regulatory T cells in atherogenesis.
Sasaki N, Yamashita T, Takeda M, Hirata K. Sasaki N, et al. Among authors: yamashita t. J Atheroscler Thromb. 2012;19(6):503-15. doi: 10.5551/jat.10934. Epub 2012 Apr 10. J Atheroscler Thromb. 2012. PMID: 22498766 Free article. Review.
It has become apparent that various types of cells of innate and adaptive immunity participate in atherogenesis. T cells are of particular interest because they mediate pathogenic immune responses involved in the acceleration of atherosclerosis. Recent studies from several …
It has become apparent that various types of cells of innate and adaptive immunity participate in atherogenesis. T cells are of parti …
Stem-like progenitor and terminally differentiated T(FH)-like CD4(+) T cell exhaustion in the tumor microenvironment.
Zhou W, Kawashima S, Ishino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Kawazu M, Dansako H, Suzuki Y, Nishikawa H, Inozume T, Nagasaki J, Togashi Y. Zhou W, et al. Among authors: yamashita k. Cell Rep. 2024 Feb 27;43(2):113797. doi: 10.1016/j.celrep.2024.113797. Epub 2024 Feb 15. Cell Rep. 2024. PMID: 38363680 Free article.
Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8(+) T cells, induces CD4(+) follicular helper T (T(FH)) cell infiltration, contributing to anti-tumor immunity. ...Our findings provide dee …
Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8(+) T cells, …
Breadth and Durability of SARS-CoV-2-Specific T Cell Responses following Long-Term Recovery from COVID-19.
Dang TTT, Anzurez A, Nakayama-Hosoya K, Miki S, Yamashita K, de Souza M, Matano T, Kawana-Tachikawa A. Dang TTT, et al. Among authors: yamashita k. Microbiol Spectr. 2023 Aug 17;11(4):e0214323. doi: 10.1128/spectrum.02143-23. Epub 2023 Jul 10. Microbiol Spectr. 2023. PMID: 37428088 Free PMC article.
Comprehensive screening of T cell responses at the peptide level was conducted for spike (S) and nucleocapsid (N) proteins, and regions frequently targeted by T cells were identified. ...While broad T cell responses were induced against both proteins, the rat …
Comprehensive screening of T cell responses at the peptide level was conducted for spike (S) and nucleocapsid (N) proteins, and regio …
12,910 results
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