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Page 1
Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
Acta Neuropathol Commun. 2020 Oct 7;8(1):164. doi: 10.1186/s40478-020-01039-9.
Acta Neuropathol Commun. 2020.
PMID: 33028421
Free PMC article.
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ.
Wu JJ, et al. Among authors: tatman m.
Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15230-15241. doi: 10.1073/pnas.1917371117. Epub 2020 Jun 8.
Proc Natl Acad Sci U S A. 2020.
PMID: 32513711
Free PMC article.
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UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.
Phung TH, Tatman M, Monteiro MJ.
Phung TH, et al. Among authors: tatman m.
Biochim Biophys Acta Gen Subj. 2023 Feb;1867(2):130284. doi: 10.1016/j.bbagen.2022.130284. Epub 2022 Nov 21.
Biochim Biophys Acta Gen Subj. 2023.
PMID: 36423739
Free PMC article.
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