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Page 1
Prion neurotoxicity.
Le NTT, Wu B, Harris DA. Le NTT, et al. Brain Pathol. 2019 Mar;29(2):263-277. doi: 10.1111/bpa.12694. Epub 2019 Jan 17. Brain Pathol. 2019. PMID: 30588688 Free PMC article. Review.
Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA. Fang C, et al. Among authors: le ntt. PLoS Pathog. 2018 Sep 20;14(9):e1007283. doi: 10.1371/journal.ppat.1007283. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30235355 Free PMC article.
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ. Wu JJ, et al. Among authors: le ntt. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15230-15241. doi: 10.1073/pnas.1917371117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513711 Free PMC article.
Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, Wong PC, Monteiro MJ. Le NT, et al. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7580-E7589. doi: 10.1073/pnas.1608432113. Epub 2016 Nov 9. Proc Natl Acad Sci U S A. 2016. PMID: 27834214 Free PMC article.