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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity.
Cell Mol Immunol. 2024 Mar;21(3):260-274. doi: 10.1038/s41423-024-01124-2. Epub 2024 Jan 18.
Cell Mol Immunol. 2024.
PMID: 38233562
Free PMC article.
Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle.
Lightman SM, Utley A, Lee KP.
Lightman SM, et al.
Front Immunol. 2019 May 3;10:965. doi: 10.3389/fimmu.2019.00965. eCollection 2019.
Front Immunol. 2019.
PMID: 31130955
Free PMC article.
Review.
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CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival.
Utley A, Chavel C, Lightman S, Holling GA, Cooper J, Peng P, Liu W, Barwick BG, Gavile CM, Maguire O, Murray-Dupuis M, Rozanski C, Jordan MS, Kambayashi T, Olejniczak SH, Boise LH, Lee KP.
Utley A, et al. Among authors: lightman s.
Cell Rep. 2020 Jun 23;31(12):107815. doi: 10.1016/j.celrep.2020.107815.
Cell Rep. 2020.
PMID: 32579940
Free PMC article.
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Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA.
Bianchi-Smiraglia A, et al. Among authors: lightman sm.
J Clin Invest. 2018 Oct 1;128(10):4682-4696. doi: 10.1172/JCI70712. Epub 2018 Sep 10.
J Clin Invest. 2018.
PMID: 30198908
Free PMC article.
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Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses.
Lightman SM, Peresie JL, Carlson LM, Holling GA, Honikel MM, Chavel CA, Nemeth MJ, Olejniczak SH, Lee KP.
Lightman SM, et al.
Immunity. 2021 Dec 14;54(12):2772-2783.e5. doi: 10.1016/j.immuni.2021.10.005. Epub 2021 Nov 16.
Immunity. 2021.
PMID: 34788602
Free PMC article.
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