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Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia.
Cell Rep Med. 2024 May 21;5(5):101521. doi: 10.1016/j.xcrm.2024.101521. Epub 2024 Apr 22.
Cell Rep Med. 2024.
PMID: 38653245
Free PMC article.
Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition.
Tambe M, Karjalainen E, Vähä-Koskela M, Bulanova D, Gjertsen BT, Kontro M, Porkka K, Heckman CA, Wennerberg K.
Tambe M, et al. Among authors: karjalainen e.
Leukemia. 2020 Dec;34(12):3186-3196. doi: 10.1038/s41375-020-0972-0. Epub 2020 Jul 10.
Leukemia. 2020.
PMID: 32651543
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Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.
Tang J, Tanoli ZU, Ravikumar B, Alam Z, Rebane A, Vähä-Koskela M, Peddinti G, van Adrichem AJ, Wakkinen J, Jaiswal A, Karjalainen E, Gautam P, He L, Parri E, Khan S, Gupta A, Ali M, Yetukuri L, Gustavsson AL, Seashore-Ludlow B, Hersey A, Leach AR, Overington JP, Repasky G, Wennerberg K, Aittokallio T.
Tang J, et al. Among authors: karjalainen e.
Cell Chem Biol. 2018 Feb 15;25(2):224-229.e2. doi: 10.1016/j.chembiol.2017.11.009. Epub 2017 Dec 21.
Cell Chem Biol. 2018.
PMID: 29276046
Free PMC article.
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Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models.
Chalabi Hajkarim M, Karjalainen E, Osipovitch M, Dimopoulos K, Gordon SL, Ambri F, Rasmussen KD, Grønbæk K, Helin K, Wennerberg K, Won KJ.
Chalabi Hajkarim M, et al. Among authors: karjalainen e.
Elife. 2022 Feb 15;11:e73760. doi: 10.7554/eLife.73760.
Elife. 2022.
PMID: 35166670
Free PMC article.
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