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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 1
2010 4
2011 1
2012 1
2013 8
2014 6
2015 4
2016 5
2017 1
2018 3
2019 1
2020 4
2021 2
2022 1
2023 2
2024 3

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36 results

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Page 1
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Grandjean JMD, et al. Among authors: smith e. Nat Chem Biol. 2020 Oct;16(10):1052-1061. doi: 10.1038/s41589-020-0584-z. Epub 2020 Jul 20. Nat Chem Biol. 2020. PMID: 32690944 Free PMC article.
Target-based discovery of a broad-spectrum flukicide.
Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Sprague DJ, et al. Among authors: smith e. Nat Struct Mol Biol. 2024 May 7. doi: 10.1038/s41594-024-01298-3. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38714890
Target-based discovery of a broad spectrum flukicide.
Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS. Sprague DJ, et al. Among authors: smith e. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.559026. doi: 10.1101/2023.09.22.559026. bioRxiv. 2023. PMID: 37790347 Free PMC article. Updated. Preprint.
Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity.
Gentry PR, Kokubo M, Bridges TM, Daniels JS, Niswender CM, Smith E, Chase P, Hodder PS, Rosen H, Conn PJ, Engers J, Brewer KA, Wood MR, Lindsley CW. Gentry PR, et al. Among authors: smith e. 2013 Dec 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2013 Dec 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 25834910 Free Books & Documents. Review.
Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core.
Gentry PR, Kokubo M, Bridges TM, Daniels JS, Niswender CM, Smith E, Chase P, Hodder PS, Rosen H, Conn PJ, Engers J, Brewer KA, Lindsley CW, Wood MR. Gentry PR, et al. Among authors: smith e. 2013 Dec 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2013 Dec 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 25834908 Free Books & Documents. Review.
Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM).
Gentry PR, Kokubo M, Bridges TM, Daniels JS, Niswender CM, Smith E, Chase P, Hodder PS, Rosen H, Conn PJ, Engers J, Brewer KA, Wood MR, Lindsley CW. Gentry PR, et al. Among authors: smith e. 2013 Dec 9 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2013 Dec 9 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 25506971 Free Books & Documents. Review.
Identification of Selective Agonists of the Transient Receptor Potential Channels 3 (TRPML3).
Saldanha SA, Grimm C, Allais C, Smith E, Ouizem S, Mercer BA, Roush WR, Heller S, Hodder P. Saldanha SA, et al. Among authors: smith e. 2012 Mar 21 [updated 2013 Sep 3]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2012 Mar 21 [updated 2013 Sep 3]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 24260779 Free Books & Documents. Review.
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2.
Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Baillargeon P, Scampavia L, Strutzenberg T, Griffin PR, Farzan M, Spicer TP. Smith E, et al. SLAS Discov. 2020 Dec;25(10):1152-1161. doi: 10.1177/2472555220963667. Epub 2020 Oct 10. SLAS Discov. 2020. PMID: 33043784 Free PMC article.
36 results