The SARS-CoV-2 main protease M(pro) causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M.
Wenzel J, et al. Among authors: pasparakis m.
Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21.
Nat Neurosci. 2021.
PMID: 34675436
Free PMC article.
We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M(pro)) cleaves NEMO, the essential modulator of nuclear factor-kappaB. By ablating NEMO, M(pro) induces the death of human brain endothelial cells and the occur …
We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M(pro)) cleaves NEMO, the es …