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Development, validation and method stability study of a LC-MS method to quantify leuprolide (Hormone analog) in human plasma.
Skiba M, Fatmi S, Elkasri N, Karrout Y, Lahiani-Skiba M. Skiba M, et al. Among authors: lahiani skiba m. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Dec 1;1160:122345. doi: 10.1016/j.jchromb.2020.122345. Epub 2020 Aug 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2020. PMID: 32920482
Multiple reaction monitoring (MRM) with a tandem mass spectrometer was used to detect the analytes. Precursor to product ion transitions of: m/z 605.5 m/z 110.2 and m/z 609.1 m/z 249.1 were used to quantify leuprolide and leuprolide-(13)C(6)-(15)N, res …
Multiple reaction monitoring (MRM) with a tandem mass spectrometer was used to detect the analytes. Precursor to product ion transitions of: …
Amorphous solid dispersion studies of camptothecin-cyclodextrin inclusion complexes in PEG 6000.
Fatmi S, Bournine L, Iguer-Ouada M, Lahiani-Skiba M, Bouchal F, Skiba M. Fatmi S, et al. Among authors: lahiani skiba m. Acta Pol Pharm. 2015 Jan-Feb;72(1):179-92. Acta Pol Pharm. 2015. PMID: 25850214 Free article.
Dissolution studies showed that percentage of CPT alone after two hour in 0.1 M HCI medium, did not exceed 16%, whereas under the same conditions, CPT/PMbeta-CD complex reached 76%. ...
Dissolution studies showed that percentage of CPT alone after two hour in 0.1 M HCI medium, did not exceed 16%, whereas under the sam …