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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: cozzani a. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma.
Hasan Bou Issa L, Fléchon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial IM, Kluza J, Manier S. Hasan Bou Issa L, et al. Among authors: cozzani a. iScience. 2024 Mar 4;27(4):109417. doi: 10.1016/j.isci.2024.109417. eCollection 2024 Apr 19. iScience. 2024. PMID: 38510131 Free PMC article.
A potential role of preexisting inflammation in the development of acute myelopathy following CAR T-cell therapy for diffuse large B-cell lymphoma.
Beauvais D, Cozzani A, Blaise AS, Moreau AS, Varlet P, Gaggero S, Alidjinou EK, Vannod-Michel Q, Morschhauser F, Labalette M, Yakoub-Agha I, Mitra S. Beauvais D, et al. Among authors: cozzani a. Curr Res Transl Med. 2022 May;70(2):103331. doi: 10.1016/j.retram.2021.103331. Epub 2022 Jan 6. Curr Res Transl Med. 2022. PMID: 34999480
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nasrallah R, Imianowski CJ, Bossini-Castillo L, Grant FM, Dogan M, Placek L, Kozhaya L, Kuo P, Sadiyah F, Whiteside SK, Mumbach MR, Glinos D, Vardaka P, Whyte CE, Lozano T, Fujita T, Fujii H, Liston A, Andrews S, Cozzani A, Yang J, Mitra S, Lugli E, Chang HY, Unutmaz D, Trynka G, Roychoudhuri R. Nasrallah R, et al. Among authors: cozzani a. Nature. 2020 Jul;583(7816):447-452. doi: 10.1038/s41586-020-2296-7. Epub 2020 May 13. Nature. 2020. PMID: 32499651 Free PMC article.