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Ectromelia Virus Affects Mitochondrial Network Morphology, Distribution, and Physiology in Murine Fibroblasts and Macrophage Cell Line.
Gregorczyk KP, Wyżewski Z, Szczepanowska J, Toka FN, Mielcarska MB, Bossowska-Nowicka M, Gieryńska M, Boratyńska-Jasińska A, Struzik J, Niemiałtowski MG, Szulc-Dąbrowska L. Gregorczyk KP, et al. Among authors: szulc dabrowska l. Viruses. 2018 May 16;10(5):266. doi: 10.3390/v10050266. Viruses. 2018. PMID: 29772718 Free PMC article.
Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Bossowska-Nowicka M, Mielcarska MB, Romaniewicz M, Kaczmarek MM, Gregorczyk-Zboroch KP, Struzik J, Grodzik M, Gieryńska MM, Toka FN, Szulc-Dąbrowska L. Bossowska-Nowicka M, et al. Among authors: szulc dabrowska l. BMC Microbiol. 2019 May 10;19(1):92. doi: 10.1186/s12866-019-1471-1. BMC Microbiol. 2019. PMID: 31077130 Free PMC article.
RESULTS: Our results showed that ECTV-infection of JAWS II DCs and primary murine GM-CSF-derived bone marrow cells down-regulated both mRNA and protein of cathepsin B, L and S, and cystatin B and C, particularly during the later stages of infection. Moreover, the activity …
RESULTS: Our results showed that ECTV-infection of JAWS II DCs and primary murine GM-CSF-derived bone marrow cells down-regulated both mRNA …
Deficiency of Selected Cathepsins Does Not Affect the Inhibitory Action of ECTV on Immune Properties of Dendritic Cells.
Bossowska-Nowicka M, Mielcarska MB, Struzik J, Jackowska-Tracz A, Tracz M, Gregorczyk-Zboroch KP, Gieryńska M, Toka FN, Szulc-Dąbrowska L. Bossowska-Nowicka M, et al. Among authors: szulc dabrowska l. Immunol Invest. 2020 Apr;49(3):232-248. doi: 10.1080/08820139.2019.1631843. Epub 2019 Jun 26. Immunol Invest. 2020. PMID: 31240969
Therefore, this study was aimed to determine if downregulation of cathepsins, such as B, L or S, disrupts cDC capacity to induce activating signals in T cells or whether infection of cDCs with ECTV further weakens their functions as antigen-presenting cells. Our results sh …
Therefore, this study was aimed to determine if downregulation of cathepsins, such as B, L or S, disrupts cDC capacity to induce acti …