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Page 1
Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery.
FEBS J. 2016 Apr;283(7):1184-96. doi: 10.1111/febs.13672. Epub 2016 Feb 18.
FEBS J. 2016.
PMID: 26876563
Free article.
Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms.
Wun SJ, Johnson LA, You L, McGeary RP, Brueck T, Schenk G, Guddat LW.
Wun SJ, et al.
Arch Biochem Biophys. 2020 Oct 15;692:108516. doi: 10.1016/j.abb.2020.108516. Epub 2020 Aug 1.
Arch Biochem Biophys. 2020.
PMID: 32745463
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Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Keough DT, Wun SJ, Baszczyňski O, Eng WS, Špaček P, Panjikar S, Naesens L, Pohl R, Rejman D, Hocková D, Ferrero RL, Guddat LW.
Keough DT, et al. Among authors: wun sj.
J Med Chem. 2021 May 13;64(9):5710-5729. doi: 10.1021/acs.jmedchem.0c02184. Epub 2021 Apr 23.
J Med Chem. 2021.
PMID: 33891818
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Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads.
Kandale A, Patel K, Hussein WM, Wun SJ, Zheng S, Tan L, West NP, Schenk G, Guddat LW, McGeary RP.
Kandale A, et al. Among authors: wun sj.
J Med Chem. 2021 Feb 11;64(3):1670-1684. doi: 10.1021/acs.jmedchem.0c01919. Epub 2021 Jan 29.
J Med Chem. 2021.
PMID: 33512163
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Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol-Acid Reductoisomerase.
Lin X, Kurz JL, Patel KM, Wun SJ, Hussein WM, Lonhienne T, West NP, McGeary RP, Schenk G, Guddat LW.
Lin X, et al. Among authors: wun sj.
Chemistry. 2021 Feb 10;27(9):3130-3141. doi: 10.1002/chem.202004665. Epub 2021 Jan 12.
Chemistry. 2021.
PMID: 33215746
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Herbicides That Target Acetohydroxyacid Synthase Are Potent Inhibitors of the Growth of Drug-Resistant Candida auris.
Agnew-Francis KA, Tang Y, Lin X, Low YS, Wun SJ, Kuo A, Elias SMAS, Lonhienne T, Condon ND, Pimentel BNAS, Vergani CE, Smith MT, Fraser JA, Williams CM, Guddat LW.
Agnew-Francis KA, et al. Among authors: wun sj.
ACS Infect Dis. 2020 Nov 13;6(11):2901-2912. doi: 10.1021/acsinfecdis.0c00229. Epub 2020 Oct 22.
ACS Infect Dis. 2020.
PMID: 32986949
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