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Page 1
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
Leca J, Lemonnier F, Meydan C, Foox J, El Ghamrasni S, Mboumba DL, Duncan GS, Fortin J, Sakamoto T, Tobin C, Hodgson K, Haight J, Smith LK, Elia AJ, Butler D, Berger T, de Leval L, Mason CE, Melnick A, Gaulard P, Mak TW. Leca J, et al. Cancer Cell. 2023 Feb 13;41(2):323-339.e10. doi: 10.1016/j.ccell.2023.01.003. Epub 2023 Feb 2. Cancer Cell. 2023. PMID: 36736318 Free article.
Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.
Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Iovanna JL, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S. Gouirand V, et al. Among authors: leca j. EMBO J. 2022 May 2;41(9):e110466. doi: 10.15252/embj.2021110466. Epub 2022 Mar 21. EMBO J. 2022. PMID: 35307861 Free PMC article.
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
Fortin J, Chiang MF, Meydan C, Foox J, Ramachandran P, Leca J, Lemonnier F, Li WY, Gams MS, Sakamoto T, Chu M, Tobin C, Laugesen E, Robinson TM, You-Ten A, Butler DJ, Berger T, Minden MD, Levine RL, Guidos CJ, Melnick AM, Mason CE, Mak TW. Fortin J, et al. Among authors: leca j. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208176120. doi: 10.1073/pnas.2208176120. Epub 2023 Jan 18. Proc Natl Acad Sci U S A. 2023. PMID: 36652477 Free PMC article.
Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.
Leca J, Martinez S, Lac S, Nigri J, Secq V, Rubis M, Bressy C, Sergé A, Lavaut MN, Dusetti N, Loncle C, Roques J, Pietrasz D, Bousquet C, Garcia S, Granjeaud S, Ouaissi M, Bachet JB, Brun C, Iovanna JL, Zimmermann P, Vasseur S, Tomasini R. Leca J, et al. J Clin Invest. 2016 Nov 1;126(11):4140-4156. doi: 10.1172/JCI87734. Epub 2016 Oct 4. J Clin Invest. 2016. PMID: 27701147 Free PMC article.
LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker.
Bressy C, Lac S, Nigri J, Leca J, Roques J, Lavaut MN, Secq V, Guillaumond F, Bui TT, Pietrasz D, Granjeaud S, Bachet JB, Ouaissi M, Iovanna J, Vasseur S, Tomasini R. Bressy C, et al. Among authors: leca j. Cancer Res. 2018 Feb 15;78(4):909-921. doi: 10.1158/0008-5472.CAN-15-2790. Epub 2017 Dec 21. Cancer Res. 2018. PMID: 29269518
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
Guillaumond F, Leca J, Olivares O, Lavaut MN, Vidal N, Berthezène P, Dusetti NJ, Loncle C, Calvo E, Turrini O, Iovanna JL, Tomasini R, Vasseur S. Guillaumond F, et al. Among authors: leca j. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3919-24. doi: 10.1073/pnas.1219555110. Epub 2013 Feb 13. Proc Natl Acad Sci U S A. 2013. PMID: 23407165 Free PMC article.