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Page 1
4'-O-substitutions determine selectivity of aminoglycoside antibiotics.
Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC. Perez-Fernandez D, et al. Among authors: duscha s. Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112. Nat Commun. 2014. PMID: 24473108 Free PMC article.
Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC. Akbergenov R, et al. Among authors: duscha s. EMBO Rep. 2018 Nov;19(11):e46193. doi: 10.15252/embr.201846193. Epub 2018 Sep 20. EMBO Rep. 2018. PMID: 30237157 Free PMC article.
Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis.
Shcherbakov D, Teo Y, Boukari H, Cortes-Sanchon A, Mantovani M, Osinnii I, Moore J, Juskeviciene R, Brilkova M, Duscha S, Kumar HS, Laczko E, Rehrauer H, Westhof E, Akbergenov R, Böttger EC. Shcherbakov D, et al. Among authors: duscha s. Commun Biol. 2019 Oct 17;2:381. doi: 10.1038/s42003-019-0626-9. eCollection 2019. Commun Biol. 2019. PMID: 31637312 Free PMC article.
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC. Matt T, et al. Among authors: duscha s. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. doi: 10.1073/pnas.1204073109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699498 Free PMC article.
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE. Bruhn DF, et al. Among authors: duscha s. Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572. Sci Transl Med. 2015. PMID: 25995221 Free PMC article.