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Year Number of Results
2011 1
2012 1
2013 1
2014 2
2015 1
2016 3
2017 2
2018 3
2020 2
2021 1
2024 0

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15 results

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Page 1
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J. Rogawski DS, et al. Among authors: klossowski s. Nat Commun. 2021 May 14;12(1):2792. doi: 10.1038/s41467-021-23152-6. Nat Commun. 2021. PMID: 33990599 Free PMC article.
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. Svoboda LK, et al. Among authors: klossowski s. J Pathol. 2018 Jul;245(3):324-336. doi: 10.1002/path.5085. Epub 2018 May 28. J Pathol. 2018. PMID: 29672864 Free PMC article.
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, Linhares BM, Chen D, Jih G, Perkey E, Huang H, He M, Wen B, Wang Y, Yu K, Lee SC, Danet-Desnoyers G, Trotman W, Kandarpa M, Cotton A, Abdel-Wahab O, Lei H, Dou Y, Guzman M, Peterson L, Gruber T, Choi S, Sun D, Ren P, Li LS, Liu Y, Burrows F, Maillard I, Cierpicki T, Grembecka J. Klossowski S, et al. J Clin Invest. 2020 Feb 3;130(2):981-997. doi: 10.1172/JCI129126. J Clin Invest. 2020. PMID: 31855575 Free PMC article.
Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, Chlebowska J, Prochorec-Sobieszek M, Winiarska M, Ostaszewski R, Gwizdalska I, Golab J, Nowis D, Firczuk M. Trzeciecka A, et al. Among authors: klossowski s. Oncotarget. 2016 Jan 12;7(2):1717-31. doi: 10.18632/oncotarget.6435. Oncotarget. 2016. PMID: 26636537 Free PMC article.
Adenanthin targets proteins involved in the regulation of disulphide bonds.
Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, Trzeciecka A, Kłossowski S, Ostaszewski R, Zagożdżon R, Pu JX, Sun HD, Golab J. Muchowicz A, et al. Among authors: klossowski s. Biochem Pharmacol. 2014 May 15;89(2):210-6. doi: 10.1016/j.bcp.2014.02.022. Epub 2014 Mar 11. Biochem Pharmacol. 2014. PMID: 24630929
Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
Borkin D, Klossowski S, Pollock J, Miao H, Linhares BM, Kempinska K, Jin Z, Purohit T, Wen B, He M, Sun D, Cierpicki T, Grembecka J. Borkin D, et al. Among authors: klossowski s. J Med Chem. 2018 Jun 14;61(11):4832-4850. doi: 10.1021/acs.jmedchem.8b00071. Epub 2018 May 23. J Med Chem. 2018. PMID: 29738674 Free PMC article.
15 results