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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma.
Agliardi G, Liuzzi AR, Hotblack A, De Feo D, Núñez N, Stowe CL, Friebel E, Nannini F, Rindlisbacher L, Roberts TA, Ramasawmy R, Williams IP, Siow BM, Lythgoe MF, Kalber TL, Quezada SA, Pule MA, Tugues S, Straathof K, Becher B. Agliardi G, et al. Among authors: hotblack a. Nat Commun. 2021 Jan 19;12(1):444. doi: 10.1038/s41467-020-20599-x. Nat Commun. 2021. PMID: 33469002 Free PMC article.
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Śledzińska A, Vila de Mucha M, Bergerhoff K, Hotblack A, Demane DF, Ghorani E, Akarca AU, Marzolini MAV, Solomon I, Vargas FA, Pule M, Ono M, Seddon B, Kassiotis G, Ariyan CE, Korn T, Marafioti T, Lord GM, Stauss H, Jenner RG, Peggs KS, Quezada SA. Śledzińska A, et al. Among authors: hotblack a. Immunity. 2020 Jan 14;52(1):151-166.e6. doi: 10.1016/j.immuni.2019.12.007. Epub 2020 Jan 7. Immunity. 2020. PMID: 31924474 Free PMC article.
Fine-tuning CARs for best performance.
Hotblack A, Straathof K. Hotblack A, et al. Cancer Cell. 2022 Jan 10;40(1):11-13. doi: 10.1016/j.ccell.2021.12.010. Cancer Cell. 2022. PMID: 35016025 Free article.
Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein-Protein Interaction.
Jha R, Kinna A, Hotblack A, Bughda R, Bulek A, Gannon I, Ilca T, Allen C, Lamb K, Dolor A, Scott I, Parekh F, Sillibourne J, Cordoba S, Onuoha S, Thomas S, Ferrari M, Pule M. Jha R, et al. Among authors: hotblack a. ACS Chem Biol. 2024 Feb 16;19(2):308-324. doi: 10.1021/acschembio.3c00521. Epub 2024 Jan 20. ACS Chem Biol. 2024. PMID: 38243811 Free PMC article.
11 results