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2021 | 4 |
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Page 1
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Alzheimers Dement. 2021 Aug;17(8):1365-1382. doi: 10.1002/alz.12302. Epub 2021 Feb 8.
Alzheimers Dement. 2021.
PMID: 33559354
Free PMC article.
Clinical Trial.
Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.
Limegrover CS, Yurko R, Izzo NJ, LaBarbera KM, Rehak C, Look G, Rishton G, Safferstein H, Catalano SM.
Limegrover CS, et al.
J Neurosci Res. 2021 Apr;99(4):1161-1176. doi: 10.1002/jnr.24782. Epub 2021 Jan 22.
J Neurosci Res. 2021.
PMID: 33480104
Free PMC article.
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Alzheimer's protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity.
Limegrover CS, LeVine H 3rd, Izzo NJ, Yurko R, Mozzoni K, Rehak C, Sadlek K, Safferstein H, Catalano SM.
Limegrover CS, et al.
J Neurochem. 2021 May;157(4):1316-1330. doi: 10.1111/jnc.15212. Epub 2020 Oct 25.
J Neurochem. 2021.
PMID: 33025581
Free PMC article.
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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Rishton GM, Look GC, Ni ZJ, Zhang J, Wang Y, Huang Y, Wu X, Izzo NJ, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Catalano SM.
Rishton GM, et al. Among authors: limegrover cs.
ACS Med Chem Lett. 2021 Aug 9;12(9):1389-1395. doi: 10.1021/acsmedchemlett.1c00048. eCollection 2021 Sep 9.
ACS Med Chem Lett. 2021.
PMID: 34531947
Free PMC article.
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