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The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib.
Villaume MT, Arrate MP, Ramsey HE, Sunthankar KI, Jenkins MT, Moyo TK, Smith BN, Fischer MA, Childress MA, Gorska AE, Ferrell PB, Savona MR. Villaume MT, et al. Among authors: arrate mp. Exp Hematol. 2021 May;97:57-65.e5. doi: 10.1016/j.exphem.2021.02.008. Epub 2021 Feb 19. Exp Hematol. 2021. PMID: 33617893 Free PMC article.
Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.
Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM. Grieb BC, et al. Cancer Res. 2014 Jul 1;74(13):3591-602. doi: 10.1158/0008-5472.CAN-13-2149. Epub 2014 May 1. Cancer Res. 2014. PMID: 24786788 Free PMC article.
JAM2 interacts with alpha4beta1. Facilitation by JAM3.
Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA. Cunningham SA, et al. Among authors: arrate mp. J Biol Chem. 2002 Aug 2;277(31):27589-92. doi: 10.1074/jbc.C200331200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070135 Free article.