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Did you mean james k harman[Author] (10 results)?
Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics.
He H, Baka T, Balschi J, Motani AS, Nguyen KK, Liu Q, Slater R, Rock B, Wang C, Hale C, Karamanlidis G, Hartman JJ, Malik FI, Reagan JD, Luptak I. He H, et al. Among authors: hartman jj. Circ Heart Fail. 2022 Mar;15(3):e009195. doi: 10.1161/CIRCHEARTFAILURE.121.009195. Epub 2021 Nov 8. Circ Heart Fail. 2022. PMID: 34743528 Free PMC article.
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.
Donkervoort S, van de Locht M, Ronchi D, Reunert J, McLean CA, Zaki M, Orbach R, de Winter JM, Conijn S, Hoomoedt D, Neto OLA, Magri F, Viaene AN, Foley AR, Gorokhova S, Bolduc V, Hu Y, Acquaye N, Napoli L, Park JH, Immadisetty K, Miles LB, Essawi M, McModie S, Ferreira LF, Zanotti S, Neuhaus SB, Medne L, ElBagoury N, Johnson KR, Zhang Y, Laing NG, Davis MR, Bryson-Richardson RJ, Hwee DT, Hartman JJ, Malik FI, Kekenes-Huskey PM, Comi GP, Sharaf-Eldin W, Marquardt T, Ravenscroft G, Bönnemann CG, Ottenheijm CAC. Donkervoort S, et al. Among authors: hartman jj. Sci Transl Med. 2024 Apr 3;16(741):eadg2841. doi: 10.1126/scitranslmed.adg2841. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569017
Supraphysiological levels of GDF11 induce striated muscle atrophy.
Hammers DW, Merscham-Banda M, Hsiao JY, Engst S, Hartman JJ, Sweeney HL. Hammers DW, et al. Among authors: hartman jj. EMBO Mol Med. 2017 Apr;9(4):531-544. doi: 10.15252/emmm.201607231. EMBO Mol Med. 2017. PMID: 28270449 Free PMC article.
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats.
Collibee SE, Romero A, Muci AR, Hwee DT, Chuang C, Hartman JJ, Motani AS, Ashcraft L, DeRosier A, Grillo M, Lu Q, Malik FI, Morgan BP. Collibee SE, et al. Among authors: hartman jj. J Med Chem. 2024 May 23;67(10):7859-7869. doi: 10.1021/acs.jmedchem.3c02412. Epub 2024 Mar 7. J Med Chem. 2024. PMID: 38451215 Free PMC article.
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery.
Huang G, Bisaria A, Wakefield DL, Yamawaki TM, Luo X, Zhang JA, Vigneault P, Wang J, Reagan JD, Oliverio O, Zhou H, Li CM, Vila OF, Wang S, Malik FI, Hartman JJ, Hale CM. Huang G, et al. Among authors: hartman jj. Stem Cell Reports. 2023 Jan 10;18(1):220-236. doi: 10.1016/j.stemcr.2022.11.008. Epub 2022 Dec 15. Stem Cell Reports. 2023. PMID: 36525964 Free PMC article.
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Sirigu S, Hartman JJ, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu PP, Barrett E, Rudolph K, Royer C, Morgan BP, Stura EA, Malik FI, Houdusse AM. Sirigu S, et al. Among authors: hartman jj. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455. doi: 10.1073/pnas.1609342113. Epub 2016 Nov 4. Proc Natl Acad Sci U S A. 2016. PMID: 27815532 Free PMC article.
17 results