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Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing.
Franck S, Couvreu De Deckersberg E, Bubenik JL, Markouli C, Barbé L, Allemeersch J, Hilven P, Duqué G, Swanson MS, Gheldof A, Spits C, Sermon KD. Franck S, et al. Among authors: couvreu de deckersberg e. Biol Open. 2022 Jan 15;11(1):bio058978. doi: 10.1242/bio.058978. Epub 2022 Jan 12. Biol Open. 2022. PMID: 35019138 Free PMC article.
Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight.
Mertens J, Belva F, van Montfoort APA, Regin M, Zambelli F, Seneca S, Couvreu de Deckersberg E, Bonduelle M, Tournaye H, Stouffs K, Barbé K, Smeets HJM, Van de Velde H, Sermon K, Blockeel C, Spits C. Mertens J, et al. Among authors: couvreu de deckersberg e. Nat Commun. 2024 Feb 9;15(1):1232. doi: 10.1038/s41467-024-45446-1. Nat Commun. 2024. PMID: 38336715 Free PMC article.
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm.
Dziedzicka D, Tewary M, Keller A, Tilleman L, Prochazka L, Östblom J, Couvreu De Deckersberg E, Markouli C, Franck S, Van Nieuwerburgh F, Spits C, Zandstra PW, Sermon K, Geens M. Dziedzicka D, et al. Among authors: couvreu de deckersberg e. Sci Rep. 2021 Mar 17;11(1):6137. doi: 10.1038/s41598-021-85447-4. Sci Rep. 2021. PMID: 33731744 Free PMC article.
Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally.
Mertens J, Regin M, De Munck N, Couvreu de Deckersberg E, Belva F, Sermon K, Tournaye H, Blockeel C, Van de Velde H, Spits C. Mertens J, et al. Among authors: couvreu de deckersberg e. Hum Mol Genet. 2022 Oct 28;31(21):3629-3642. doi: 10.1093/hmg/ddac059. Hum Mol Genet. 2022. PMID: 35285472 Free PMC article.