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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21.
Cell Metab. 2021.
PMID: 33887198
Free PMC article.
Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice.
Richardson NE, Konon EN, Schuster HS, Mitchell AT, Boyle C, Rodgers AC, Finke M, Haider LR, Yu D, Flores V, Pak HH, Ahmad S, Ahmed S, Radcliff A, Wu J, Williams EM, Abdi L, Sherman DS, Hacker T, Lamming DW.
Richardson NE, et al. Among authors: konon en.
Nat Aging. 2021 Jan;1(1):73-86. doi: 10.1038/s43587-020-00006-2. Epub 2021 Jan 14.
Nat Aging. 2021.
PMID: 33796866
Free PMC article.
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Restoration of metabolic health by decreased consumption of branched-chain amino acids.
Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW.
Cummings NE, et al. Among authors: konon en.
J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27.
J Physiol. 2018.
PMID: 29266268
Free PMC article.
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The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome.
Pak HH, Cummings NE, Green CL, Brinkman JA, Yu D, Tomasiewicz JL, Yang SE, Boyle C, Konon EN, Ong IM, Lamming DW.
Pak HH, et al. Among authors: konon en.
Sci Rep. 2019 Jan 11;9(1):67. doi: 10.1038/s41598-018-37177-3.
Sci Rep. 2019.
PMID: 30635612
Free PMC article.
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