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Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers.
JCI Insight. 2022 Nov 22;7(22):e158060. doi: 10.1172/jci.insight.158060.
JCI Insight. 2022.
PMID: 36256477
Free PMC article.
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME.
Tolosa EJ, et al. Among authors: horn ip.
Biochem J. 2020 Sep 18;477(17):3131-3145. doi: 10.1042/BCJ20200335.
Biochem J. 2020.
PMID: 32766732
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A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.
Horn IP, Marks DL, Koenig AN, Hogenson TL, Almada LL, Goldstein LE, Romecin Duran PA, Vera R, Vrabel AM, Cui G, Rabe KG, Bamlet WR, Mer G, Sicotte H, Zhang C, Li H, Petersen GM, Fernandez-Zapico ME.
Horn IP, et al.
J Biol Chem. 2021 Jan-Jun;296:100634. doi: 10.1016/j.jbc.2021.100634. Epub 2021 Apr 3.
J Biol Chem. 2021.
PMID: 33823155
Free PMC article.
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Genetic Testing Utilization: Discrepancies Between Somatic and Germline Results in Patients With Cancer Reviewed at the UW Health Precision Medicine Molecular Tumor Board.
Horn IP, Zakas AL, Smith-Simmer KJ, Birkeland LE, Sundstrom R, Burkard ME, Weiss JM.
Horn IP, et al.
JCO Precis Oncol. 2024 May;8:e2300466. doi: 10.1200/PO.23.00466.
JCO Precis Oncol. 2024.
PMID: 38810171
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