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MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.
Sigaud R, Albert TK, Hess C, Hielscher T, Winkler N, Kocher D, Walter C, Münter D, Selt F, Usta D, Ecker J, Brentrup A, Hasselblatt M, Thomas C, Varghese J, Capper D, Thomale UW, Hernáiz Driever P, Simon M, Horn S, Herz NA, Koch A, Sahm F, Hamelmann S, Faria-Andrade A, Jabado N, Schuhmann MU, Schouten-van Meeteren AYN, Hoving E, Brummer T, van Tilburg CM, Pfister SM, Witt O, Jones DTW, Kerl K, Milde T. Sigaud R, et al. Among authors: kocher d. Nat Commun. 2023 Jul 27;14(1):4533. doi: 10.1038/s41467-023-40235-8. Nat Commun. 2023. PMID: 37500667 Free PMC article.
The white matter is a pro-differentiative niche for glioblastoma.
Brooks LJ, Clements MP, Burden JJ, Kocher D, Richards L, Devesa SC, Zakka L, Woodberry M, Ellis M, Jaunmuktane Z, Brandner S, Morrison G, Pollard SM, Dirks PB, Marguerat S, Parrinello S. Brooks LJ, et al. Among authors: kocher d. Nat Commun. 2021 Apr 12;12(1):2184. doi: 10.1038/s41467-021-22225-w. Nat Commun. 2021. PMID: 33846316 Free PMC article.
Author Correction: The white matter is a pro-differentiative niche for glioblastoma.
Brooks LJ, Clements MP, Burden JJ, Kocher D, Richards L, Devesa SC, Zakka L, Woodberry M, Ellis M, Jaunmuktane Z, Brandner S, Morrison G, Pollard SM, Dirks PB, Marguerat S, Parrinello S. Brooks LJ, et al. Among authors: kocher d. Nat Commun. 2022 Apr 14;13(1):2163. doi: 10.1038/s41467-022-29916-y. Nat Commun. 2022. PMID: 35422055 Free PMC article. No abstract available.
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.
Selt F, El Damaty A, Schuhmann MU, Sigaud R, Ecker J, Sievers P, Kocher D, Herold-Mende C, Oehme I, von Deimling A, Pfister SM, Sahm F, Jones DTW, Witt O, Milde T. Selt F, et al. Among authors: kocher d. J Neurooncol. 2023 Dec;165(3):467-478. doi: 10.1007/s11060-023-04500-6. Epub 2023 Nov 24. J Neurooncol. 2023. PMID: 37999877 Free PMC article.
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R. Kocher D, et al. J Neurooncol. 2024 Jun;168(2):317-332. doi: 10.1007/s11060-024-04672-9. Epub 2024 Apr 17. J Neurooncol. 2024. PMID: 38630384 Free PMC article.