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P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2.
Cell Rep. 2023 Dec 26;42(12):113501. doi: 10.1016/j.celrep.2023.113501. Epub 2023 Nov 30.
Cell Rep. 2023.
PMID: 38039128
Free article.
Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3.
Leser C, Keller M, Gerndt S, Urban N, Chen CC, Schaefer M, Grimm C, Bracher F.
Leser C, et al.
Eur J Med Chem. 2021 Jan 15;210:112966. doi: 10.1016/j.ejmech.2020.112966. Epub 2020 Oct 24.
Eur J Med Chem. 2021.
PMID: 33187805
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Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.
Rautenberg S, Keller M, Leser C, Chen CC, Bracher F, Grimm C.
Rautenberg S, et al. Among authors: leser c.
Handb Exp Pharmacol. 2023;278:249-276. doi: 10.1007/164_2022_605.
Handb Exp Pharmacol. 2023.
PMID: 35902436
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Effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans-ML-SI3.
Kriegler K, Leser C, Mayer P, Bracher F.
Kriegler K, et al. Among authors: leser c.
Arch Pharm (Weinheim). 2022 Feb;355(2):e2100362. doi: 10.1002/ardp.202100362. Epub 2021 Nov 5.
Arch Pharm (Weinheim). 2022.
PMID: 34738656
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Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Rühl P, Rosato AS, Urban N, Gerndt S, Tang R, Abrahamian C, Leser C, Sheng J, Jha A, Vollmer G, Schaefer M, Bracher F, Grimm C.
Rühl P, et al. Among authors: leser c.
Sci Rep. 2021 Apr 15;11(1):8313. doi: 10.1038/s41598-021-87817-4.
Sci Rep. 2021.
PMID: 33859333
Free PMC article.
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