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15 results

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Page 1
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, Rojas JM, Quinn WJ 3rd, Cheng EP, Konon EN, Haider LR, Finke M, Sonsalla M, Alexander CM, Rabinowitz JD, Baur JA, Malecki KC, Lamming DW. Yu D, et al. Among authors: brinkman ja. Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21. Cell Metab. 2021. PMID: 33887198 Free PMC article.
Hypothalamic mTORC2 is essential for metabolic health and longevity.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW. Chellappa K, et al. Among authors: brinkman ja. Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1. Aging Cell. 2019. PMID: 31373126 Free PMC article.
Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.
De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, Merrins MJ. De Leon ER, et al. Among authors: brinkman ja. Sci Rep. 2018 Dec 13;8(1):17814. doi: 10.1038/s41598-018-36289-0. Sci Rep. 2018. PMID: 30546031 Free PMC article.
A novel rapamycin analog is highly selective for mTORC1 in vivo.
Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, Lamming DW. Schreiber KH, et al. Among authors: brinkman ja. Nat Commun. 2019 Jul 19;10(1):3194. doi: 10.1038/s41467-019-11174-0. Nat Commun. 2019. PMID: 31324799 Free PMC article.
Chronic intermittent hypoxia worsens bleomycin-induced lung fibrosis in rats.
Braun RK, Broytman O, Braun FM, Brinkman JA, Clithero A, Modi D, Pegelow DF, Eldridge M, Teodorescu M. Braun RK, et al. Among authors: brinkman ja. Respir Physiol Neurobiol. 2018 Oct;256:97-108. doi: 10.1016/j.resp.2017.04.010. Epub 2017 Apr 27. Respir Physiol Neurobiol. 2018. PMID: 28456608 Free PMC article.
Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism.
Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BW. Li Z, et al. Among authors: brinkman ja. Cell Metab. 2020 Apr 7;31(4):741-754.e5. doi: 10.1016/j.cmet.2020.02.015. Epub 2020 Mar 19. Cell Metab. 2020. PMID: 32197071 Free PMC article.
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