Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN.
Cui M, et al. Among authors: bassel duby r.
Nat Commun. 2021 Sep 6;12(1):5270. doi: 10.1038/s41467-021-25653-w.
Nat Commun. 2021.
PMID: 34489413
Free PMC article.
Conversely, Nrf1 overexpression protected the adult mouse heart from ischemia/reperfusion (I/R) injury. Nrf1 also protected human induced pluripotent stem cell-derived cardiomyocytes from doxorubicin-induced cardiotoxicity and other cardiotoxins. ...
Conversely, Nrf1 overexpression protected the adult mouse heart from ischemia/reperfusion (I/R) injury. Nrf1 also protected human ind …