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SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening.
Gorshkov K, Morales Vasquez D, Chiem K, Ye C, Nguyen Tran B, Carlos de la Torre J, Moran T, Chen CZ, Martinez-Sobrido L, Zheng W. Gorshkov K, et al. Among authors: nguyen tran b. ACS Pharmacol Transl Sci. 2022 Jan 3;5(1):8-19. doi: 10.1021/acsptsci.1c00182. eCollection 2022 Jan 14. ACS Pharmacol Transl Sci. 2022. PMID: 35036857 Free PMC article.
The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Tran BN, Cheng YS, Xu M, Pradhan M, Henderson M, Zhu W, Oh E, Susumu K, Wolak M, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Carlos de la Torre J, Simeonov A, Michael SG, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: tran bn. ACS Infect Dis. 2021 Jun 11;7(6):1389-1408. doi: 10.1021/acsinfecdis.0c00349. Epub 2020 Dec 21. ACS Infect Dis. 2021. PMID: 33346633 Free PMC article.
The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Xu M, Pradhan M, Tran BN, Zhu W, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Simeonov A, Michael S, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: tran bn. bioRxiv [Preprint]. 2020 May 28:2020.05.16.091520. doi: 10.1101/2020.05.16.091520. bioRxiv. 2020. PMID: 32511355 Free PMC article. Updated. Preprint.
Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
Ilnytska O, Lai K, Gorshkov K, Schultz ML, Tran BN, Jeziorek M, Kunkel TJ, Azaria RD, McLoughlin HS, Waghalter M, Xu Y, Schlame M, Altan-Bonnet N, Zheng W, Lieberman AP, Dobrowolski R, Storch J. Ilnytska O, et al. Among authors: tran bn. J Biol Chem. 2021 Jul;297(1):100813. doi: 10.1016/j.jbc.2021.100813. Epub 2021 May 21. J Biol Chem. 2021. PMID: 34023384 Free PMC article.