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Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
J Med Chem. 2020 Apr 9;63(7):3538-3551. doi: 10.1021/acs.jmedchem.9b01851. Epub 2020 Mar 23.
J Med Chem. 2020.
PMID: 32134266
Free PMC article.
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS.
Sun RC, et al. Among authors: mahalingan kk.
Cell Metab. 2021 Jul 6;33(7):1404-1417.e9. doi: 10.1016/j.cmet.2021.05.003. Epub 2021 May 26.
Cell Metab. 2021.
PMID: 34043942
Free PMC article.
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Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
Buchman CD, Mahalingan KK, Hurley TD.
Buchman CD, et al. Among authors: mahalingan kk.
Chem Biol Interact. 2015 Jun 5;234:38-44. doi: 10.1016/j.cbi.2014.12.038. Epub 2015 Jan 29.
Chem Biol Interact. 2015.
PMID: 25641190
Free PMC article.
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Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
Mahalingan KK, Baskaran S, DePaoli-Roach AA, Roach PJ, Hurley TD.
Mahalingan KK, et al.
Biochemistry. 2017 Jan 10;56(1):179-188. doi: 10.1021/acs.biochem.6b00884. Epub 2016 Dec 20.
Biochemistry. 2017.
PMID: 27935293
Free PMC article.
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