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In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.
Young LEA, Conroy LR, Clarke HA, Hawkinson TR, Bolton KE, Sanders WC, Chang JE, Webb MB, Alilain WJ, Vander Kooi CW, Drake RR, Andres DA, Badgett TC, Wagner LM, Allison DB, Sun RC, Gentry MS. Young LEA, et al. Among authors: sanders wc. EMBO Mol Med. 2022 Nov 8;14(11):e16029. doi: 10.15252/emmm.202216029. Epub 2022 Sep 5. EMBO Mol Med. 2022. PMID: 36059248 Free PMC article.
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome.
Juras JA, Webb MB, Young LEA, Markussen KH, Hawkinson TR, Buoncristiani MD, Bolton KE, Coburn PT, Williams MI, Sun LPY, Sanders WC, Bruntz RC, Conroy LR, Wang C, Gentry MS, Smith BN, Sun RC. Juras JA, et al. Among authors: sanders wc. Cell Rep Methods. 2023 Apr 18;3(4):100455. doi: 10.1016/j.crmeth.2023.100455. eCollection 2023 Apr 24. Cell Rep Methods. 2023. PMID: 37159672 Free PMC article.
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS. Sun RC, et al. Among authors: sanders wc. Cell Metab. 2021 Jul 6;33(7):1404-1417.e9. doi: 10.1016/j.cmet.2021.05.003. Epub 2021 May 26. Cell Metab. 2021. PMID: 34043942 Free PMC article.