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The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age.
Cegielski J, Brook MS, Phillips BE, Boereboom C, Gates A, Gladman JFR, Smith K, Wilkinson DJ, Atherton PJ. Cegielski J, et al. Among authors: gladman jfr. Geroscience. 2022 Aug;44(4):2129-2138. doi: 10.1007/s11357-022-00541-3. Epub 2022 Mar 18. Geroscience. 2022. PMID: 35303223 Free PMC article. Clinical Trial.
Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a 'Combined Oral Stable Isotope Assessment of Muscle (COSIAM)' approach.
Cegielski J, Wilkinson DJ, Brook MS, Boereboom C, Phillips BE, Gladman JFR, Smith K, Atherton PJ. Cegielski J, et al. Among authors: gladman jfr. Geroscience. 2021 Dec;43(6):2653-2665. doi: 10.1007/s11357-021-00386-2. Epub 2021 May 27. Geroscience. 2021. PMID: 34046811 Free PMC article.