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Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs.
Mol Ther. 2021 Nov 3;29(11):3293-3304. doi: 10.1016/j.ymthe.2021.06.004. Epub 2021 Jun 4.
Mol Ther. 2021.
PMID: 34091054
Free PMC article.
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR.
Parhiz H, et al. Among authors: natesan a.
J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23.
J Control Release. 2022.
PMID: 34953981
Free PMC article.
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