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Page 1
Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML.
Cell Rep Med. 2023 Nov 21;4(11):101290. doi: 10.1016/j.xcrm.2023.101290.
Cell Rep Med. 2023.
PMID: 37992684
Free PMC article.
The Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms.
Ferng TT, Terada D, Ando M, Tarver TC, Chaudhary F, Lin KC, Logan AC, Smith CC.
Ferng TT, et al. Among authors: tarver tc.
Mol Cancer Ther. 2022 May 4;21(5):844-854. doi: 10.1158/1535-7163.MCT-21-0317.
Mol Cancer Ther. 2022.
PMID: 35395091
Free PMC article.
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Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
Smith CC, Viny AD, Massi E, Kandoth C, Socci ND, Rapaport F, Najm M, Medina-Martinez JS, Papaemmanuil E, Tarver TC, Hsu HH, Le MH, West B, Bollag G, Taylor BS, Levine RL, Shah NP.
Smith CC, et al. Among authors: tarver tc.
Clin Cancer Res. 2021 Jul 15;27(14):4003-4011. doi: 10.1158/1078-0432.CCR-20-3458. Epub 2021 Jun 8.
Clin Cancer Res. 2021.
PMID: 34103301
Free PMC article.
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Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations.
Tarver TC, Hill JE, Rahmat L, Perl AE, Bahceci E, Mori K, Smith CC.
Tarver TC, et al.
Blood Adv. 2020 Feb 11;4(3):514-524. doi: 10.1182/bloodadvances.2019000919.
Blood Adv. 2020.
PMID: 32040554
Free PMC article.
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