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Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.
El-Dershaby NH, El-Hawash SA, Kassab SE, Dabees HG, Abdel Moneim AE, Abdel Wahab IA, Abd-Alhaseeb MM, El-Miligy MMM. El-Dershaby NH, et al. Among authors: el miligy mmm. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1737-1751. doi: 10.1080/14756366.2022.2086868. J Enzyme Inhib Med Chem. 2022. PMID: 35707920 Free PMC article.
Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs.
El-Dershaby NH, El-Hawash SA, Kassab SE, Daabees HG, Abdel Moneim AE, El-Miligy MMM. El-Dershaby NH, et al. Among authors: el miligy mmm. Pharmaceuticals (Basel). 2022 Sep 20;15(10):1165. doi: 10.3390/ph15101165. Pharmaceuticals (Basel). 2022. PMID: 36297278 Free PMC article.
Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis.
Abdelaziz ME, El-Miligy MMM, Fahmy SM, Abu-Serie MM, Hazzaa AA, Mahran MA. Abdelaziz ME, et al. Among authors: el miligy mmm. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2304044. doi: 10.1080/14756366.2024.2304044. Epub 2024 Jan 17. J Enzyme Inhib Med Chem. 2024. PMID: 38230430 Free PMC article.