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Page 1
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.
Sci Transl Med. 2021 Jul 28;13(604):eabe1923. doi: 10.1126/scitranslmed.abe1923.
Sci Transl Med. 2021.
PMID: 34321318
Free PMC article.
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.
Rothstein JD, Baskerville V, Rapuri S, Mehlhop E, Jafar-Nejad P, Rigo F, Bennett F, Mizielinska S, Isaacs A, Coyne AN.
Rothstein JD, et al. Among authors: baskerville v.
Acta Neuropathol. 2023 Nov 29;147(1):1. doi: 10.1007/s00401-023-02652-3.
Acta Neuropathol. 2023.
PMID: 38019311
Free PMC article.
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SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
Baskerville V, Rapuri S, Mehlhop E, Coyne AN.
Baskerville V, et al.
Brain. 2024 Jan 4;147(1):109-121. doi: 10.1093/brain/awad291.
Brain. 2024.
PMID: 37639327
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