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PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration.
Sassano ML, van Vliet AR, Vervoort E, Van Eygen S, Van den Haute C, Pavie B, Roels J, Swinnen JV, Spinazzi M, Moens L, Casteels K, Meyts I, Pinton P, Marchi S, Rochin L, Giordano F, Felipe-Abrio B, Agostinis P. Sassano ML, et al. Among authors: van eygen s. J Cell Biol. 2023 Mar 6;222(3):e202206008. doi: 10.1083/jcb.202206008. Epub 2023 Feb 23. J Cell Biol. 2023. PMID: 36821088 Free PMC article.
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Rufo N, Korovesis D, Van Eygen S, Derua R, Garg AD, Finotello F, Vara-Perez M, Rožanc J, Dewaele M, de Witte PA, Alexopoulos LG, Janssens S, Sinkkonen L, Sauter T, Verhelst SHL, Agostinis P. Rufo N, et al. Among authors: van eygen s. Cell Death Differ. 2022 Jan;29(1):230-245. doi: 10.1038/s41418-021-00853-5. Epub 2021 Aug 27. Cell Death Differ. 2022. PMID: 34453119 Free PMC article.
Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing.
Garg AD, Vandenberk L, Fang S, Fasche T, Van Eygen S, Maes J, Van Woensel M, Koks C, Vanthillo N, Graf N, de Witte P, Van Gool S, Salven P, Agostinis P. Garg AD, et al. Among authors: van eygen s. Cell Death Differ. 2017 May;24(5):832-843. doi: 10.1038/cdd.2017.15. Epub 2017 Feb 24. Cell Death Differ. 2017. PMID: 28234357 Free PMC article.
The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling.
van Vliet AR, Giordano F, Gerlo S, Segura I, Van Eygen S, Molenberghs G, Rocha S, Houcine A, Derua R, Verfaillie T, Vangindertael J, De Keersmaecker H, Waelkens E, Tavernier J, Hofkens J, Annaert W, Carmeliet P, Samali A, Mizuno H, Agostinis P. van Vliet AR, et al. Among authors: van eygen s. Mol Cell. 2017 Mar 2;65(5):885-899.e6. doi: 10.1016/j.molcel.2017.01.020. Epub 2017 Feb 23. Mol Cell. 2017. PMID: 28238652 Free article.