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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 4
1977 4
1978 2
1979 4
1980 4
1981 4
1982 2
1983 3
1984 3
1985 5
1986 3
1987 1
1989 6
1990 3
1991 6
1992 3
1993 7
1994 5
1995 4
1996 6
1997 4
1998 9
1999 4
2000 2
2001 5
2002 3
2003 2
2004 1
2005 3
2006 6
2007 8
2008 10
2009 12
2010 5
2011 13
2012 7
2013 11
2014 15
2015 18
2016 10
2017 14
2018 12
2019 13
2020 10
2021 17
2022 14
2023 8
2024 5

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291 results

Results by year

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Page 1
Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.
Denkert C, von Minckwitz G, Darb-Esfahani S, Lederer B, Heppner BI, Weber KE, Budczies J, Huober J, Klauschen F, Furlanetto J, Schmitt WD, Blohmer JU, Karn T, Pfitzner BM, Kümmel S, Engels K, Schneeweiss A, Hartmann A, Noske A, Fasching PA, Jackisch C, van Mackelenbergh M, Sinn P, Schem C, Hanusch C, Untch M, Loibl S. Denkert C, et al. Among authors: karn t. Lancet Oncol. 2018 Jan;19(1):40-50. doi: 10.1016/S1470-2045(17)30904-X. Epub 2017 Dec 7. Lancet Oncol. 2018. PMID: 29233559
A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon.
Khan D, Terenzi F, Liu G, Ghosh PK, Ye F, Nguyen K, China A, Ramachandiran I, Chakraborty S, Stefan J, Khan K, Vasu K, Dong F, Willard B, Karn J, Gack MU, Fox PL. Khan D, et al. Among authors: karn j. Nat Commun. 2023 Jun 9;14(1):3385. doi: 10.1038/s41467-023-39091-3. Nat Commun. 2023. PMID: 37296097 Free PMC article.
The cell biology of HIV-1 latency and rebound.
Mbonye U, Karn J. Mbonye U, et al. Among authors: karn j. Retrovirology. 2024 Apr 5;21(1):6. doi: 10.1186/s12977-024-00639-w. Retrovirology. 2024. PMID: 38580979 Free PMC article. Review.
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4(+) T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source of the viral rebound that almost inevitably follows the inte …
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4(+) T cells, pos …
The Molecular Basis for Human Immunodeficiency Virus Latency.
Mbonye U, Karn J. Mbonye U, et al. Among authors: karn j. Annu Rev Virol. 2017 Sep 29;4(1):261-285. doi: 10.1146/annurev-virology-101416-041646. Epub 2017 Jul 17. Annu Rev Virol. 2017. PMID: 28715973 Review.
Although potent combination antiretroviral therapy can effectively block viral replication in the host, human immunodeficiency virus (HIV) persists due to the existence of latent but replication-competent proviruses residing primarily in a very small population of resting memory …
Although potent combination antiretroviral therapy can effectively block viral replication in the host, human immunodeficiency virus (HIV) p …
New insights into transcription elongation control of HIV-1 latency and rebound.
Mbonye U, Kizito F, Karn J. Mbonye U, et al. Among authors: karn j. Trends Immunol. 2023 Jan;44(1):60-71. doi: 10.1016/j.it.2022.11.003. Epub 2022 Dec 8. Trends Immunol. 2023. PMID: 36503686 Review.
Studies on the molecular mechanisms leading to HIV-1 latency and reactivation are being transformed using latency models in primary and patient CD4(+) T cells. These studies have revealed the central role played by the biogenesis of the transcription elongation factor P-TE …
Studies on the molecular mechanisms leading to HIV-1 latency and reactivation are being transformed using latency models in primary and pati …
Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.
Rheinberger M, Costa AL, Kampmann M, Glavas D, Shytaj IL, Sreeram S, Penzo C, Tibroni N, Garcia-Mesa Y, Leskov K, Fackler OT, Vlahovicek K, Karn J, Lucic B, Herrmann C, Lusic M. Rheinberger M, et al. Among authors: karn j. Cell Rep. 2023 Feb 28;42(2):112110. doi: 10.1016/j.celrep.2023.112110. Epub 2023 Feb 13. Cell Rep. 2023. PMID: 36790927 Free article.
Here, we determine HIV-1 integration sites (ISs), associate them with chromatin and expression signatures at different genomic scales in a microglia cell model, and profile them together with the primary T cell reservoir. HIV-1 insertions into introns of actively transcrib …
Here, we determine HIV-1 integration sites (ISs), associate them with chromatin and expression signatures at different genomic scales in a m …
Breast cancers with high proliferation and low ER-related signalling have poor prognosis and unique molecular features with implications for therapy.
Licata L, Barreca M, Galbardi B, Dugo M, Viale G, Győrffy B, Karn T, Pusztai L, Gianni L, Callari M, Bianchini G. Licata L, et al. Among authors: karn t. Br J Cancer. 2023 Dec;129(12):2025-2033. doi: 10.1038/s41416-023-02477-7. Epub 2023 Nov 7. Br J Cancer. 2023. PMID: 37935787 Free PMC article.
TCGA was used to assess the mutational landscape and biomarkers associated with palbociclib-resistance (Cyclin-E, RBsig, IRPR) and immunotherapy-response (TMB, TILs, T-cell inflamed) by MKS/ERS-subgroups. RESULTS: Compared to MKS(hi)/ERS(hi) tumours, MKS(hi)/ERS(lo) tumour …
TCGA was used to assess the mutational landscape and biomarkers associated with palbociclib-resistance (Cyclin-E, RBsig, IRPR) and immunothe …
Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer.
Blenman KRM, Marczyk M, Karn T, Qing T, Li X, Gunasekharan V, Yaghoobi V, Bai Y, Ibrahim EY, Park T, Silber A, Wolf DM, Reisenbichler E, Denkert C, Sinn BV, Rozenblit M, Foldi J, Rimm DL, Loibl S, Pusztai L. Blenman KRM, et al. Among authors: karn t. Clin Cancer Res. 2022 Jun 13;28(12):2587-2597. doi: 10.1158/1078-0432.CCR-21-3215. Clin Cancer Res. 2022. PMID: 35377948 Free PMC article. Clinical Trial.
Immune-rich bTNBC with RD was enriched in CCL-3, -4, -5, -8, -23, CXCL-1, -3, -6, -10, and IL1, -23, -27, -34, and had higher expression of macrophage markers compared with immune-rich cancers with pCR that were enriched in IFNgamma, IL2, -12, -21, chemokines CXCL-9, -13, CXCR5, …
Immune-rich bTNBC with RD was enriched in CCL-3, -4, -5, -8, -23, CXCL-1, -3, -6, -10, and IL1, -23, -27, -34, and had higher expression of …
Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial.
Miller JS, Davis ZB, Helgeson E, Reilly C, Thorkelson A, Anderson J, Lima NS, Jorstad S, Hart GT, Lee JH, Safrit JT, Wong H, Cooley S, Gharu L, Chung H, Soon-Shiong P, Dobrowolski C, Fletcher CV, Karn J, Douek DC, Schacker TW. Miller JS, et al. Among authors: karn j. Nat Med. 2022 Feb;28(2):392-400. doi: 10.1038/s41591-021-01651-9. Epub 2022 Jan 31. Nat Med. 2022. PMID: 35102335 Clinical Trial.
In exploratory analyses, N-803 was associated with proliferation and/or activation of CD4(+) and CD8(+) T cells and natural killer cells that peaked at 4 d after dosing. IFN-gamma, IP-10, MCP-1 and IL-15 increased during treatment. HIV transcription in memory CD4 T …
In exploratory analyses, N-803 was associated with proliferation and/or activation of CD4(+) and CD8(+) T cells and natural killer ce …
291 results