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2024 | 1 |
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The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806.
Blood. 2022.
PMID: 34582559
Free PMC article.
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Aubrey BJ, Cutler JA, Bourgeois W, Donovan KA, Gu S, Hatton C, Perlee S, Perner F, Rahnamoun H, Theall ACP, Henrich JA, Zhu Q, Nowak RP, Kim YJ, Parvin S, Cremer A, Olsen SN, Eleuteri NA, Pikman Y, McGeehan GM, Stegmaier K, Letai A, Fischer ES, Liu XS, Armstrong SA.
Aubrey BJ, et al. Among authors: henrich ja.
Nat Cancer. 2022 May;3(5):595-613. doi: 10.1038/s43018-022-00366-1. Epub 2022 May 9.
Nat Cancer. 2022.
PMID: 35534777
Free PMC article.
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Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Bourgeois W, Cutler JA, Aubrey BJ, Wenge DV, Perner F, Martucci C, Henrich JA, Klega K, Nowak RP, Donovan KA, Boileau M, Wen Y, Hatton C, Apazidis AA, Olsen SN, Kirmani N, Pikman Y, Pollard JA, Perry JA, Sperling AS, Ebert BL, McGeehan GM, Crompton BD, Fischer ES, Armstrong SA.
Bourgeois W, et al. Among authors: henrich ja.
Blood. 2024 Apr 11;143(15):1513-1527. doi: 10.1182/blood.2023021105.
Blood. 2024.
PMID: 38096371
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