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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions.
Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5.
Autophagy. 2022.
PMID: 34740311
Free PMC article.
GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition.
Bestion E, Jilkova ZM, Mège JL, Novello M, Kurma K, Pour STA, Lalmanach G, Vanderlynden L, Fizanne L, Bassissi F, Rachid M, Tracz J, Boursier J, Courcambeck J, Serdjebi C, Ansaldi C, Decaens T, Halfon P, Brun S.
Bestion E, et al. Among authors: tracz j.
Ther Adv Chronic Dis. 2020 Jul 16;11:2040622320942042. doi: 10.1177/2040622320942042. eCollection 2020.
Ther Adv Chronic Dis. 2020.
PMID: 32728410
Free PMC article.
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GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.
Brun S, Bassissi F, Serdjebi C, Novello M, Tracz J, Autelitano F, Guillemot M, Fabre P, Courcambeck J, Ansaldi C, Raymond E, Halfon P.
Brun S, et al. Among authors: tracz j.
Invest New Drugs. 2019 Dec;37(6):1135-1145. doi: 10.1007/s10637-019-00741-3. Epub 2019 Feb 19.
Invest New Drugs. 2019.
PMID: 30778887
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Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.
Gouarné C, Tardif G, Tracz J, Latyszenok V, Michaud M, Clemens LE, Yu-Taeger L, Nguyen HP, Bordet T, Pruss RM.
Gouarné C, et al. Among authors: tracz j.
PLoS One. 2013 Nov 26;8(11):e81528. doi: 10.1371/journal.pone.0081528. eCollection 2013.
PLoS One. 2013.
PMID: 24303051
Free PMC article.
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