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Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.
Cell Chem Biol. 2022 Mar 17;29(3):398-411.e4. doi: 10.1016/j.chembiol.2021.10.011. Epub 2021 Nov 10.
Cell Chem Biol. 2022.
PMID: 34762849
Free article.
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3.
Wachholz V, Mustafa AM, Zeyn Y, Henninger SJ, Beyer M, Dzulko M, Piée-Staffa A, Brachetti C, Haehnel PS, Sellmer A, Mahboobi S, Kindler T, Brenner W, Nikolova T, Krämer OH.
Wachholz V, et al. Among authors: henninger sj.
Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
Arch Toxicol. 2022.
PMID: 34665271
Free PMC article.
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A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
Sellmer A, Pilsl B, Beyer M, Pongratz H, Wirth L, Elz S, Dove S, Henninger SJ, Spiekermann K, Polzer H, Klaeger S, Kuster B, Böhmer FD, Fiebig HH, Krämer OH, Mahboobi S.
Sellmer A, et al.
Eur J Med Chem. 2020 May 1;193:112232. doi: 10.1016/j.ejmech.2020.112232. Epub 2020 Mar 13.
Eur J Med Chem. 2020.
PMID: 32199135
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