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A Reasonable Evaluation of Chuanxiong Rhizoma Processing with Wine through Comparative Pharmacokinetic Study of Bioactive Components: Dominant Effect on Middle Cerebral Artery Occlusion Model Rats.
Pei K, Cao L, Cao G, Cai H, Ning Y, Zhao T, Sun L, Liu H, Zhang S. Pei K, et al. Among authors: cai h. J Anal Methods Chem. 2022 Mar 14;2022:8252038. doi: 10.1155/2022/8252038. eCollection 2022. J Anal Methods Chem. 2022. PMID: 35321518 Free PMC article.
The results showed that the maximum plasma concentrations, the area values under the concentration-time curves of senkyunolide A, and ferulic acid in wine-processed Chuanxiong Rhizoma were all higher than in raw Chuanxiong Rhizoma, which were completely opposite to …
The results showed that the maximum plasma concentrations, the area values under the concentration-time curves of senkyunolide A, and feruli …
A Network-Based Approach to Investigate the Neuroprotective Effects and Mechanisms of Action of Huangqi-Chuanxiong and Sanleng-Ezhu Herb Pairs in the Treatment of Cerebral Ischemic Stroke.
Zhao L, Ding LD, Xia ZH, Sheng P, Shen MM, Cai ZM, Yan BC. Zhao L, et al. Among authors: cai zm. Front Pharmacol. 2022 Mar 23;13:844186. doi: 10.3389/fphar.2022.844186. eCollection 2022. Front Pharmacol. 2022. PMID: 35401166 Free PMC article.
Objective: We aimed to investigate the effect and mechanisms of action of two drug pairs [Huangqi-Chuanxiong and Sanleng-Ezhu Herb (HCSE)] on the treatment of ischemic stroke. ...Results: We mined the current literature and identified a new formulation of Chinese herbs for …
Objective: We aimed to investigate the effect and mechanisms of action of two drug pairs [Huangqi-Chuanxiong and Sanleng-Ezhu Herb (H …
The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses.
Zhang J, Cai C, Luo Y, Wu Y, Qiu F. Zhang J, et al. Among authors: cai c. J Integr Neurosci. 2023 Oct 23;22(6):149. doi: 10.31083/j.jin2206149. J Integr Neurosci. 2023. PMID: 38176927 Free article.
BACKGROUND: Cerebral stroke is a leading cause of death and disability worldwide. Ligusticum Chuanxiong Hort. (LCH), a well-known Chinese herb, is widely used for the treatment of cerebral stroke. ...
BACKGROUND: Cerebral stroke is a leading cause of death and disability worldwide. Ligusticum Chuanxiong Hort. (LCH), a well-known Chi …
Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway.
Du HY, Wang R, Li JL, Luo H, Xie XY, Yan R, Jian YL, Cai JY. Du HY, et al. Among authors: cai jy. Bioengineered. 2021 Dec;12(1):507-515. doi: 10.1080/21655979.2021.1880060. Bioengineered. 2021. PMID: 33522374 Free PMC article.
Ligustrazine, an alkaloid monomer extracted from Chuanxiong Rhizoma, has the function of protecting nerve cells. However, the effect and mechanism of ligustrazine on retinal ischemia/reperfusion (I/R) injury still need to be clarified. ...
Ligustrazine, an alkaloid monomer extracted from Chuanxiong Rhizoma, has the function of protecting nerve cells. However, the effect …
Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy.
Wu JZ, Li YJ, Huang GR, Xu B, Zhou F, Liu RP, Gao F, Ge JD, Cai YJ, Zheng Q, Li XJ. Wu JZ, et al. Among authors: cai yj. Chin J Nat Med. 2021 Apr;19(4):241-254. doi: 10.1016/S1875-5364(21)60026-2. Chin J Nat Med. 2021. PMID: 33875165
Angelicae Sinensis Radix (Danggui) and Ligusticum Chuanxiong Rhizoma (Chuan Xiong) herb-pair (DC) have been frequently used in Traditional Chinese medicine (TCM) prescriptions for hundreds of years to prevent vascular diseases and alleviate pain. ...
Angelicae Sinensis Radix (Danggui) and Ligusticum Chuanxiong Rhizoma (Chuan Xiong) herb-pair (DC) have been frequently used in Tradit …
Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort.
Tang Z, Qin Y, Chen W, Zhao Z, Lin W, Xiao Y, Chen H, Liu Y, Chen H, Bu T, Li Q, Cai Y, Yao H, Wan Y. Tang Z, et al. Among authors: cai y. Front Microbiol. 2021 Nov 17;12:771000. doi: 10.3389/fmicb.2021.771000. eCollection 2021. Front Microbiol. 2021. PMID: 34867905 Free PMC article.
The objective of this study was to evaluate the diversity of endophytic fungi of different parts of Ligusticum chuanxiong Hort (CX) and further characterize their biological activities and identify chemical compounds produced by these endophytic fungi. ...
The objective of this study was to evaluate the diversity of endophytic fungi of different parts of Ligusticum chuanxiong Hort (CX) a …
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Jin Y, Cai S, Jiang Y, Zhong K, Wen C, Ruan Y, Chew LA, Khanna R, Xu Z, Yu J. Jin Y, et al. Among authors: cai s. ACS Chem Neurosci. 2019 Dec 18;10(12):4854-4863. doi: 10.1021/acschemneuro.9b00575. Epub 2019 Dec 6. ACS Chem Neurosci. 2019. PMID: 31756074
Here, we investigated the effect of tetramethylpyrazine (TMP), the main bioactive alkaloid isolated from the oriental medicine Ligusticum chuanxiong Hort., against the epileptogenesis progression of acute hippocampal and corneal (6 Hz) electrical kindling models of TLE. .. …
Here, we investigated the effect of tetramethylpyrazine (TMP), the main bioactive alkaloid isolated from the oriental medicine Ligusticum …
Comparative Study on Pharmacokinetics of Four Active Compounds in Rat Plasma after Oral Administration of Raw and Wine Processed Chuanxiong Rhizoma.
Ning Y, Pei K, Cao G, Cai H, Liu X, Cao L, Zhang S, Cai B. Ning Y, et al. Among authors: cai h, cai b. Molecules. 2019 Dec 25;25(1):93. doi: 10.3390/molecules25010093. Molecules. 2019. PMID: 31881790 Free PMC article.
In Chinese medicine, the effect of promoting blood circulation and removing stasis could be enhanced after Chuanxiong Rhizoma is processed by wine. However, the relevant mechanism remains unclear. In this manuscript, a rapid and sensitive quantification method employing ul …
In Chinese medicine, the effect of promoting blood circulation and removing stasis could be enhanced after Chuanxiong Rhizoma is proc …
Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain-gut barriers.
Chen R, Wu P, Cai Z, Fang Y, Zhou H, Lasanajak Y, Tang L, Ye L, Hou C, Zhao J. Chen R, et al. Among authors: cai z. J Nutr Biochem. 2019 Mar;65:101-114. doi: 10.1016/j.jnutbio.2018.12.004. Epub 2018 Dec 21. J Nutr Biochem. 2019. PMID: 30710886
The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. ...
The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. ...
Screening potential mitochondria-targeting compounds from traditional Chinese medicines using a mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry method.
Yang XX, Zhou YZ, Xu F, Yu J, Gegentana, Shang MY, Wang X, Cai SQ. Yang XX, et al. Among authors: cai sq. J Pharm Anal. 2018 Aug;8(4):240-249. doi: 10.1016/j.jpha.2018.06.001. Epub 2018 Jun 15. J Pharm Anal. 2018. PMID: 30140488 Free PMC article.
This method allowed searching natural mitochondria-targeting compounds from traditional Chinese medicines (TCMs), including Puerariae Radix (PR) and Chuanxiong Radix (CR). A total of 23 active compounds were successfully discovered from the two TCMs extracts. ...
This method allowed searching natural mitochondria-targeting compounds from traditional Chinese medicines (TCMs), including Puerariae Radix …
26 results