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The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background.
Banse SA, Jackson EG, Sedore CA, Onken B, Hall D, Coleman-Hulbert A, Huynh P, Garrett T, Johnson E, Harinath G, Inman D, Guo S, Morshead M, Xue J, Falkowski R, Chen E, Herrera C, Kirsch AJ, Perez VI, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Banse SA, et al. Among authors: morshead m. Aging (Albany NY). 2024 Apr 12;16(7):5829-5855. doi: 10.18632/aging.205743. Epub 2024 Apr 12. Aging (Albany NY). 2024. PMID: 38613792 Free PMC article.
Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes.
Banse SA, Sedore CA, Johnson E, Coleman-Hulbert AL, Onken B, Hall D, Jackson EG, Huynh P, Foulger AC, Guo S, Garrett T, Xue J, Inman D, Morshead ML, Plummer WT, Chen E, Bhaumik D, Chen MK, Harinath G, Chamoli M, Quinn RP, Falkowski R, Edgar D, Schmidt MO, Lucanic M, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Banse SA, et al. Among authors: morshead ml. Geroscience. 2024 Apr;46(2):2239-2251. doi: 10.1007/s11357-023-00978-0. Epub 2023 Nov 4. Geroscience. 2024. PMID: 37923874 Free PMC article.
Examining effects of a novel estrogenic perfluoro-alcohol, 1H,1H,8H,8H-Perfluorooctane-1,8-diol (FC8-diol), using the fathead minnow EcoToxChip.
Santana Rodriguez KJ, Villeneuve DL, Cavallin JE, Blackwell BR, Hoang J, Hofer RN, Jensen KM, Kahl MD, Kutsi RN, Stacy E, Morshead ML, Ankley GT. Santana Rodriguez KJ, et al. Among authors: morshead ml. Environ Toxicol Chem. 2024 Jul 3. doi: 10.1002/etc.5937. Online ahead of print. Environ Toxicol Chem. 2024. PMID: 38961679
Comparing Transcriptomic Points of Departure to Apical Effect Concentrations For Larval Fathead Minnow Exposed to Chemicals with Four Different Modes Of Action.
Flynn K, Le M, Hazemi M, Biales A, Bencic DC, Blackwell BR, Bush K, Flick R, Hoang JX, Martinson J, Morshead M, Rodriguez KS, Stacy E, Villeneuve DL. Flynn K, et al. Among authors: morshead m. Arch Environ Contam Toxicol. 2024 May;86(4):346-362. doi: 10.1007/s00244-024-01064-y. Epub 2024 May 14. Arch Environ Contam Toxicol. 2024. PMID: 38743081
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.
Onken B, Sedore CA, Coleman-Hulbert AL, Hall D, Johnson E, Jones EG, Banse SA, Huynh P, Guo S, Xue J, Chen E, Harinath G, Foulger AC, Chao EA, Hope J, Bhaumik D, Plummer T, Inman D, Morshead M, Guo M, Lithgow GJ, Phillips PC, Driscoll M. Onken B, et al. Among authors: morshead m. Aging Cell. 2022 Jan;21(1):e13488. doi: 10.1111/acel.13488. Epub 2021 Nov 27. Aging Cell. 2022. PMID: 34837316 Free PMC article.
Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.
Morshead ML, Sedore CA, Jones EG, Hall D, Plummer WT, Garrett T, Lucanic M, Guo M, Driscoll M, Phillips PC, Lithgow G. Morshead ML, et al. MicroPubl Biol. 2020 May 27;2020:10.17912/micropub.biology.000257. doi: 10.17912/micropub.biology.000257. MicroPubl Biol. 2020. PMID: 32550518 Free PMC article. No abstract available.