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Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.
Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, Schumacher TN, Tanay A, Amit I. Li H, et al. Among authors: van der leun am. Cell. 2019 Feb 7;176(4):775-789.e18. doi: 10.1016/j.cell.2018.11.043. Epub 2018 Dec 27. Cell. 2019. PMID: 30595452 Free PMC article.
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma.
Vos JL, Elbers JBW, Krijgsman O, Traets JJH, Qiao X, van der Leun AM, Lubeck Y, Seignette IM, Smit LA, Willems SM, van den Brekel MWM, Dirven R, Baris Karakullukcu M, Karssemakers L, Klop WMC, Lohuis PJFM, Schreuder WH, Smeele LE, van der Velden LA, Bing Tan I, Onderwater S, Jasperse B, Vogel WV, Al-Mamgani A, Keijser A, van der Noort V, Broeks A, Hooijberg E, Peeper DS, Schumacher TN, Blank CU, de Boer JP, Haanen JBAG, Zuur CL. Vos JL, et al. Among authors: van der leun am. Nat Commun. 2021 Dec 22;12(1):7348. doi: 10.1038/s41467-021-26472-9. Nat Commun. 2021. PMID: 34937871 Free PMC article. Clinical Trial.
The power to "di-sc-seq-t".
van der Leun AM, Haanen JB. van der Leun AM, et al. Cancer Cell. 2021 Mar 8;39(3):299-301. doi: 10.1016/j.ccell.2021.02.001. Epub 2021 Feb 11. Cancer Cell. 2021. PMID: 33577786 Free article.
An atlas of intratumoral T cells.
van der Leun AM, Schumacher TN. van der Leun AM, et al. Science. 2021 Dec 17;374(6574):1446-1447. doi: 10.1126/science.abm9244. Epub 2021 Dec 16. Science. 2021. PMID: 34914514
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.
Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, Schumacher TN, Tanay A, Amit I. Li H, et al. Among authors: van der leun am. Cell. 2020 Apr 30;181(3):747. doi: 10.1016/j.cell.2020.04.017. Cell. 2020. PMID: 32359441 Free article. No abstract available.
Harnessing human plasmacytoid dendritic cells as professional APCs.
Tel J, van der Leun AM, Figdor CG, Torensma R, de Vries IJ. Tel J, et al. Among authors: van der leun am. Cancer Immunol Immunother. 2012 Aug;61(8):1279-88. doi: 10.1007/s00262-012-1210-z. Cancer Immunol Immunother. 2012. PMID: 22294456 Free PMC article. Review.
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag.
van der Leun AM, Hoekstra ME, Reinalda L, Scheele CLGJ, Toebes M, van de Graaff MJ, Chen LYY, Li H, Bercovich A, Lubling Y, David E, Thommen DS, Tanay A, van Rheenen J, Amit I, van Kasteren SI, Schumacher TN. van der Leun AM, et al. Nat Chem Biol. 2021 Nov;17(11):1139-1147. doi: 10.1038/s41589-021-00839-x. Epub 2021 Sep 9. Nat Chem Biol. 2021. PMID: 34504322 Free PMC article.