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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Luu JC, Saadane A, Leinonen H, Choi EH, Gao F, Lewandowski D, Halabi M, Sander CL, Wu A, Wang JM, Singh R, Gao S, Lessieur EM, Dong Z, Palczewska G, Mullins RF, Peachey NS, Kiser PD, Tabaka M, Kern TS, Palczewski K. Luu JC, et al. Among authors: sander cl. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2221045120. doi: 10.1073/pnas.2221045120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126699 Free PMC article.
Structural evidence for visual arrestin priming via complexation of phosphoinositols.
Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Sander CL, et al. Structure. 2022 Feb 3;30(2):263-277.e5. doi: 10.1016/j.str.2021.10.002. Epub 2021 Oct 21. Structure. 2022. PMID: 34678158 Free PMC article.
Photic generation of 11-cis-retinal in bovine retinal pigment epithelium.
Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Zhang J, et al. Among authors: sander cl. J Biol Chem. 2019 Dec 13;294(50):19137-19154. doi: 10.1074/jbc.RA119.011169. Epub 2019 Nov 6. J Biol Chem. 2019. PMID: 31694912 Free PMC article.
A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6.
Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. Leinonen H, et al. Among authors: sander cl. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30. J Pharmacol Exp Ther. 2021. PMID: 33931547 Free PMC article.