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Quercetin treatment increases H2O2 removal by restoration of endogenous antioxidant activity and blocks isoproterenol-induced cardiac hypertrophy.
de Lacerda Alexandre JV, Viana YIP, David CEB, Cunha PLO, Albuquerque AC, Varela ALN, Kowaltowski AJ, Facundo HT. de Lacerda Alexandre JV, et al. Among authors: cunha plo. Naunyn Schmiedebergs Arch Pharmacol. 2021 Feb;394(2):217-226. doi: 10.1007/s00210-020-01953-8. Epub 2020 Sep 15. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 32930861
Pharmacological and molecular docking studies reveal that glibenclamide competitively inhibits diazoxide-induced mitochondrial ATP-sensitive potassium channel activation and pharmacological preconditioning.
Bezerra Palácio P, Brito Lucas AM, Varlla de Lacerda Alexandre J, Oliveira Cunha PL, Ponte Viana YI, Albuquerque AC, Nunes Varela AL, Facundo HT. Bezerra Palácio P, et al. Among authors: oliveira cunha pl. Eur J Pharmacol. 2021 Oct 5;908:174379. doi: 10.1016/j.ejphar.2021.174379. Epub 2021 Jul 26. Eur J Pharmacol. 2021. PMID: 34324857 Free article.
Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca2+-induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress.
Brito Lucas AM, Bezerra Palacio P, Oliveira Cunha PL, Tarso Facundo H. Brito Lucas AM, et al. Among authors: oliveira cunha pl. Free Radic Res. 2024 Mar-Apr;58(4):293-310. doi: 10.1080/10715762.2024.2342962. Epub 2024 Apr 17. Free Radic Res. 2024. PMID: 38630026