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A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
Tanton H, Sewastianik T, Seo HS, Remillard D, Pierre RS, Bala P, Aitymbayev D, Dennis P, Adler K, Geffken E, Yeoh Z, Vangos N, Garbicz F, Scott D, Sethi N, Bradner J, Dhe-Paganon S, Carrasco RD. Tanton H, et al. Sci Adv. 2022 Apr 29;8(17):eabm3108. doi: 10.1126/sciadv.abm3108. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486727 Free PMC article.
Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.
Liao Y, Chen CH, Xiao T, de la Peña Avalos B, Dray EV, Cai C, Gao S, Shah N, Zhang Z, Feit A, Xue P, Liu Z, Yang M, Lee JH, Xu H, Li W, Mei S, Pierre RS, Shu S, Fei T, Duarte M, Zhao J, Bradner JE, Polyak K, Kantoff PW, Long H, Balk SP, Liu XS, Brown M, Xu K. Liao Y, et al. Among authors: pierre rs. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2105898119. doi: 10.1073/pnas.2105898119. Proc Natl Acad Sci U S A. 2022. PMID: 35031563 Free PMC article.