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Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.
Hatit MZC, Dobrowolski CN, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Zenhausern R, Paunovska K, Peck HE, Kim J, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: dobrowolski cn. Nat Chem. 2023 Apr;15(4):508-515. doi: 10.1038/s41557-023-01138-9. Epub 2023 Mar 2. Nat Chem. 2023. PMID: 36864143
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
Hatit MZC, Lokugamage MP, Dobrowolski CN, Paunovska K, Ni H, Zhao K, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: dobrowolski cn. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. Nat Nanotechnol. 2022. PMID: 35132167 Free PMC article.
Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska K, Huayamares SG, Hua X, Han K, Loughrey D, Hatit MZC, Del Cid A, Ni H, Shajii A, Li A, Muralidharan A, Peck HE, Tiegreen KE, Jia S, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: dobrowolski cn. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307801120. doi: 10.1073/pnas.2307801120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437539 Free PMC article.