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Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.
Minisini M, Di Giorgio E, Kerschbamer E, Dalla E, Faggiani M, Franforte E, Meyer-Almes FJ, Ragno R, Antonini L, Mai A, Fiorentino F, Rotili D, Chinellato M, Perin S, Cendron L, Weichenberger CX, Angelini A, Brancolini C. Minisini M, et al. Among authors: perin s. Nucleic Acids Res. 2022 Mar 21;50(5):2566-2586. doi: 10.1093/nar/gkac081. Nucleic Acids Res. 2022. PMID: 35150567 Free PMC article.
A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue.
Mazzocato Y, Perin S, Morales-Sanfrutos J, Romanyuk Z, Pluda S, Acquasaliente L, Borsato G, De Filippis V, Scarso A, Angelini A. Mazzocato Y, et al. Among authors: perin s. Bioorg Med Chem. 2023 Nov 15;95:117499. doi: 10.1016/j.bmc.2023.117499. Epub 2023 Oct 12. Bioorg Med Chem. 2023. PMID: 37879145 Free article.