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Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
Hack V, Gross A, Kinscherf R, Bockstette M, Fiers W, Berke G, Dröge W. Hack V, et al. Among authors: kinscherf r. FASEB J. 1996 Aug;10(10):1219-26. doi: 10.1096/fasebj.10.10.8751725. FASEB J. 1996. PMID: 8751725
The findings indicate that tumor cachexia is triggered initially by IL-6 and is later sustained by processes driven by an abnormal cysteine metabolism in different organs.-Hack, V., Gross, A., Kinscherf, R., Bockstette, M., Fiers, W., Berke, G., and Droge, W. Abnormal glut …
The findings indicate that tumor cachexia is triggered initially by IL-6 and is later sustained by processes driven by an abnormal cysteine …
High Plasma Cystine Levels Are Associated with Blood Pressure and Reversed by CPAP in Patients with Obstructive Sleep Apnea.
Boneberg R, Pardun A, Hannemann L, Hildebrandt O, Koehler U, Kinscherf R, Hildebrandt W. Boneberg R, et al. Among authors: kinscherf r. J Clin Med. 2021 Mar 30;10(7):1387. doi: 10.3390/jcm10071387. J Clin Med. 2021. PMID: 33808409 Free PMC article.

CySS correlated with cumulative time at an O(2)-saturation <90% (Tu90%) (r = 0.34, p < 0.05) beside BMI (r = 0.58, p < 0.001) and was higher in subjects with "hypoxic stress" (59.4 2.0 vs. 50.1 2.7 M, p < 0.01) defined as Tu90% 15.2 min (corresponding to

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CySS correlated with cumulative time at an O(2)-saturation <90% (Tu90%) (r = 0.34, p < 0.05) beside BMI (r = 0.58, p &lt

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GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice.
Heduschke A, Ackermann K, Wilhelm B, Mey L, Bonaterra GA, Kinscherf R, Schwarz A. Heduschke A, et al. Among authors: kinscherf r. Cells. 2021 Sep 7;10(9):2346. doi: 10.3390/cells10092346. Cells. 2021. PMID: 34571994 Free PMC article.
Thus, we are interested in investigating autophagic mechanisms with special respect to the role of GDF-15. (2) Methods: Recombinant (r)GDF-15 and siRNA GDF-15 were used to investigate the effects of GDF-15 on autophagic and lysosomal activity, as well as autophagosome form …
Thus, we are interested in investigating autophagic mechanisms with special respect to the role of GDF-15. (2) Methods: Recombinant (r …
Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages.
Ackermann K, Bonaterra GA, Kinscherf R, Schwarz A. Ackermann K, et al. Among authors: kinscherf r. Atherosclerosis. 2019 Feb;281:128-136. doi: 10.1016/j.atherosclerosis.2018.12.009. Epub 2018 Dec 19. Atherosclerosis. 2019. PMID: 30658188
METHODS AND RESULTS: Oxidized-low density lipoprotein (50 mug/ml oxLDL), recombinant (r)GDF-15, transiently silenced GDF-15 (siGDF-15 Mphi), as well as with negative siRNA transfected (nsiGDF-15 Mphi) PMA-differentiated human THP-1 Mphi, were used to investigate the effect …
METHODS AND RESULTS: Oxidized-low density lipoprotein (50 mug/ml oxLDL), recombinant (r)GDF-15, transiently silenced GDF-15 (siGDF-15 …
Gene copy number effects in the mer operon of plasmid NR1.
Nakahara H, Kinscherf TG, Silver S, Miki T, Easton AM, Rownd RH. Nakahara H, et al. Among authors: kinscherf tg. J Bacteriol. 1979 Apr;138(1):284-7. doi: 10.1128/jb.138.1.284-287.1979. J Bacteriol. 1979. PMID: 374374 Free PMC article.
The level of resistance to Hg2+ determined by the inducible mer operon of plasmid NR1 was essentially the same for three gene copy number variants in Escherichia coli, less in Proteus mirabilis, and intermediate in P. mirabilis "transitioned" to a high r-determinant gene c …
The level of resistance to Hg2+ determined by the inducible mer operon of plasmid NR1 was essentially the same for three gene copy number va …
The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men.
Koenig AM, Koehler U, Hildebrandt O, Schwarzbach H, Hannemann L, Boneberg R, Heverhagen JT, Mahnken AH, Keller M, Kann PH, Deigner HP, Laur N, Kinscherf R, Hildebrandt W. Koenig AM, et al. Among authors: kinscherf r. J Endocr Soc. 2021 May 6;5(8):bvab082. doi: 10.1210/jendso/bvab082. eCollection 2021 Aug 1. J Endocr Soc. 2021. PMID: 34268461 Free PMC article.

Total FFAs and PA were significantly (by 178% and 166%) higher in OSA patients vs controls and correlated with the apnea-hypopnea index (AHI) (r 0.45, P < .01). Moreover, IMCL and EMCL were 55% (P < .05) and 40% (P < .05) higher in OSA patients, that is, 114% and

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Total FFAs and PA were significantly (by 178% and 166%) higher in OSA patients vs controls and correlated with the apnea-hypopnea index (AHI …
Muscular adaptations to computer-guided strength training with eccentric overload.
Friedmann B, Kinscherf R, Vorwald S, Müller H, Kucera K, Borisch S, Richter G, Bärtsch P, Billeter R. Friedmann B, et al. Among authors: kinscherf r. Acta Physiol Scand. 2004 Sep;182(1):77-88. doi: 10.1111/j.1365-201X.2004.01337.x. Acta Physiol Scand. 2004. PMID: 15329060
RT-PCR revealed significantly increased myosin heavy chain (MHC) IIa and lactate dehydrogenase (LDH) A mRNAs, a tendency for increased MHC IIx mRNA (P = 0.056) and high correlations between the changes in MHC IIx and LDH A mRNAs (r=0.97, P=0.001) in the CON/ECC-OVERLOAD gr …
RT-PCR revealed significantly increased myosin heavy chain (MHC) IIa and lactate dehydrogenase (LDH) A mRNAs, a tendency for increased MHC I …
Effect of thiol antioxidant on body fat and insulin reactivity.
Hildebrandt W, Hamann A, Krakowski-Roosen H, Kinscherf R, Dugi K, Sauer R, Lacher S, Nöbel N, Bodens A, Bellou V, Edler L, Nawroth P, Dröge W. Hildebrandt W, et al. Among authors: kinscherf r. J Mol Med (Berl). 2004 May;82(5):336-44. doi: 10.1007/s00109-004-0532-5. Epub 2004 Mar 6. J Mol Med (Berl). 2004. PMID: 15007512 Clinical Trial.
In two double-blind trials involving a total of 140 non-diabetic subjects we found furthermore that NAC increased the HOMA-R index (derived from the fasting insulin and glucose concentrations) in smokers and obese patients, but not in nonobese non-smokers. ...Simultaneous …
In two double-blind trials involving a total of 140 non-diabetic subjects we found furthermore that NAC increased the HOMA-R index (d …
Assessment of metabolism and microcirculation of healthy skeletal muscles by magnetic resonance and ultrasound techniques.
Weber MA, Krakowski-Roosen H, Hildebrandt W, Schröder L, Ionescu I, Krix M, Kinscherf R, Bachert P, Kauczor HU, Essig M. Weber MA, et al. Among authors: kinscherf r. J Neuroimaging. 2007 Oct;17(4):323-31. doi: 10.1111/j.1552-6569.2007.00156.x. J Neuroimaging. 2007. PMID: 17894621
Levels of high-energy phosphates, such as phosphocreatine, were positively correlated with CSA (r= .5) and histologic fiber size (r= .6 for type IIA and IIX fibers), while phosphocreatine concentration was significantly negatively correlated to myocellular lipids ( …
Levels of high-energy phosphates, such as phosphocreatine, were positively correlated with CSA (r= .5) and histologic fiber size ( …
Combinatorial Synthesis of New Pyrimidine- and Purine-β-d-Ribonucleoside Nucleolipids: Their Distribution Between Aqueous and Organic Phases and Their In Vitro Activity Against Human- and Rat Glioblastoma Cells In Vitro.
Hammerbacher K, Görtemaker K, Knies C, Bender E, Bonaterra GA, Rosemeyer H, Kinscherf R. Hammerbacher K, et al. Among authors: kinscherf r. Chem Biodivers. 2018 Sep;15(9):e1800173. doi: 10.1002/cbdv.201800173. Epub 2018 Aug 20. Chem Biodivers. 2018. PMID: 29928783
Moreover, nucleolipids were characterized by their molecular descriptor amphiphilic ratio (a.r.), which describes the balance between the hydrophilicity of the nucleoside headgroup and the lipophilicity of the lipid tail. ...
Moreover, nucleolipids were characterized by their molecular descriptor amphiphilic ratio (a.r.), which describes the balance between …
14 results